INT199153

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Context Info
Confidence 0.44
First Reported 2006
Last Reported 2006
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 1.73
Pain Relevance 0.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (RET) signal transduction (RET) plasma membrane (RET)
RET (Homo sapiens)
Pain Link Frequency Relevance Heat
Glial derived neurotrophic factor 2 84.92 Quite High
imagery 8 19.92 Low Low
Catecholamine 8 11.40 Low Low
Dopamine 2 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low
headache 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Multiple Endocrine Neoplasia Type 2b 42 92.64 High High
Multiple Endocrine Neoplasia Type 2a 122 92.56 High High
Thyroid Neoplasm 124 79.76 Quite High
Pheochromocytoma 48 75.60 Quite High
Syndrome 18 69.68 Quite High
Recurrence 2 66.32 Quite High
Hypercalcemia 16 52.12 Quite High
Cancer 36 41.56 Quite Low
Disease 10 5.00 Very Low Very Low Very Low
Metastasis 8 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
RET phosphorylated tyrosines serve as docking sites for intracellular signaling proteins.
Phosphorylation (phosphorylated) of RET
1) Confidence 0.44 Published 2006 Journal Orphanet J Rare Dis Section Body Doc Link PMC1654141 Disease Relevance 0.76 Pain Relevance 0.04
RET phosphorylated tyrosines interact with the docking protein FSR2 causing the downstream activation of the mitogen-activated protein kinase (MAPK) signaling cascade [23].
Phosphorylation (phosphorylated) of RET
2) Confidence 0.44 Published 2006 Journal Orphanet J Rare Dis Section Body Doc Link PMC1654141 Disease Relevance 0.97 Pain Relevance 0

General Comments

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