INT199187

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Context Info
Confidence 0.78
First Reported 2006
Last Reported 2010
Negated 0
Speculated 2
Reported most in Body
Documents 2
Total Number 6
Disease Relevance 3.36
Pain Relevance 1.11

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endoplasmic reticulum (Hmox1) enzyme binding (Hmox1) signal transducer activity (Hmox1)
cytosol (Hmox1) signal transduction (Hmox1) cell death (Hmox1)
Anatomy Link Frequency
liver 1
plaques 1
Hmox1 (Mus musculus)
Pain Link Frequency Relevance Heat
Hippocampus 3 99.92 Very High Very High Very High
cerebral cortex 3 99.28 Very High Very High Very High
withdrawal 16 99.22 Very High Very High Very High
Inflammation 134 94.88 High High
agonist 6 82.52 Quite High
Potency 7 77.60 Quite High
cINOD 105 71.84 Quite High
tolerance 43 69.56 Quite High
ischemia 5 35.16 Quite Low
Glutamate 15 27.52 Quite Low
Disease Link Frequency Relevance Heat
Amyloid Plaque 9 99.84 Very High Very High Very High
Stress 50 97.44 Very High Very High Very High
Hepatocellular Cancer 44 95.68 Very High Very High Very High
INFLAMMATION 174 94.88 High High
Disease 375 93.64 High High
Injury 25 93.40 High High
Adenoma 2 92.04 High High
Poisoning 4 87.84 High High
Apoptosis 35 82.76 Quite High
Necrosis 15 79.92 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Though glia cells can also exhibit antioxidative functions by releasing hemeoxygenase-1 (HO-1) triggered by accumulation of 3-hydroxyanthralinic acid (3-HAA), a down-stream product of the tryptophan metabolism.
Localization (releasing) of hemeoxygenase-1
1) Confidence 0.78 Published 2010 Journal International Journal of Alzheimer's Disease Section Body Doc Link PMC2925207 Disease Relevance 0.67 Pain Relevance 0.28
The aim of this work was to explore the liver capacity to restore homeostasis under carcinogen withdrawal analyzing the expression and cellular localization patterns of the cellular key adaptive protein HO-1 and to compare it with the continuous carcinogen administration.
Spec (analyzing) Localization (localization) of HO-1 in liver associated with withdrawal
2) Confidence 0.40 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1769509 Disease Relevance 0.40 Pain Relevance 0.09
This is of special interest since HO-1 was reported to be localized within mitochondria [49] and thereby could directly affect nitrate-induced mitochondrial ROS formation and protect ALDH-2 from oxidative inactivation (see scheme in Figure 4).
Localization (localized) of HO-1
3) Confidence 0.37 Published 2006 Journal BMC Cardiovasc Disord Section Body Doc Link PMC1654181 Disease Relevance 0.31 Pain Relevance 0.15
We analyzed HO-1 cellular localization and the expression of HO-1, Bcl-2 and cell cycle related proteins under these conditions comparing them to hepatocellular carcinoma (HC).


Spec (analyzed) Localization (localization) of HO-1 associated with hepatocellular cancer
4) Confidence 0.35 Published 2006 Journal BMC Cancer Section Abstract Doc Link PMC1769509 Disease Relevance 0.58 Pain Relevance 0.09
Though glia cells can also exhibit antioxidative functions by releasing hemeoxygenase-1 (HO-1) triggered by accumulation of 3-hydroxyanthralinic acid (3-HAA), a down-stream product of the tryptophan metabolism.
Localization (releasing) of HO-1
5) Confidence 0.23 Published 2010 Journal International Journal of Alzheimer's Disease Section Body Doc Link PMC2925207 Disease Relevance 0.67 Pain Relevance 0.28
HO-1 was found to be colocalized to senile plaques, neurofibrillary tangles, and corpora amylacea [73].
Localization (colocalized) of HO-1 in plaques associated with amyloid plaque
6) Confidence 0.22 Published 2010 Journal International Journal of Alzheimer's Disease Section Body Doc Link PMC2925207 Disease Relevance 0.72 Pain Relevance 0.22

General Comments

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