INT199192

Context Info Confidence 0.27 First Reported 2006 Last Reported 2006 Negated 1 Speculated 0 Reported most in Body Documents 1 Total Number 2 Disease Relevance 0.23 Pain Relevance 0.19

signal transducer activity (Gnat3, Hmox1) signal transduction (Gnat3, Hmox1) endoplasmic reticulum (Hmox1) enzyme binding (Hmox1) GTPase activity (Gnat3) cytoplasm (Gnat3)

Gnat3 (Mus musculus) Hmox1 (Mus musculus)

Pain Link Frequency Relevance Heat tolerance 86 89.20 Bioavailability 2 49.04 Potency 14 42.84 Inflammation 2 24.92 methotrexate 4 5.00 Angina 2 5.00

Disease Link Frequency Relevance Heat Stress 30 82.48 INFLAMMATION 2 24.92 Cardiovascular Disease 2 5.00 Cv General 3 Under Development 2 5.00 Reprotox - General 2 2 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

It is unclear why ISDN and GTN do not induce HO-1.

GTN Neg (not) Positive_regulation (induce) of HO-1

1) Confidence 0.27 Published 2006 Journal BMC Cardiovasc Disord Section Body Doc Link PMC1654181 Disease Relevance 0.08 Pain Relevance 0.07

In contrast, GTN only induced a minor increase in HO-1 mRNA which did not reach significance (Figure 3).

GTN Positive_regulation (increase) of HO-1

2) Confidence 0.20 Published 2006 Journal BMC Cardiovasc Disord Section Body Doc Link PMC1654181 Disease Relevance 0.15 Pain Relevance 0.11

General Comments

This test has worked.