INT199193

Context Info Confidence 0.08 First Reported 2006 Last Reported 2006 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.18 Pain Relevance 0.08

signal transduction (Gnat3, Ros1) cell differentiation (Ros1) GTPase activity (Gnat3) cytoplasm (Gnat3) signal transducer activity (Gnat3) cell proliferation (Ros1)

Gnat3 (Mus musculus) Ros1 (Mus musculus)

Pain Link Frequency Relevance Heat Potency 7 87.44 Inflammation 1 69.52 tolerance 43 50.00 methotrexate 2 5.00 Angina 1 5.00 Bioavailability 1 5.00

Disease Link Frequency Relevance Heat INFLAMMATION 1 69.52 Stress 15 60.56 Cardiovascular Disease 1 5.00 Cv General 3 Under Development 1 5.00 Reprotox - General 2 1 5.00

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Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

It is thought that GTN induces mitochondrial ROS formation which may contribute to oxidative inhibition of ALDH-2 activity and depletion of reduced thiols (such as dihydrolipoic acid) [38] thereby disrupting the physiological catalytic cycle (Figure 4).

GTN Positive_regulation (induces) of Gene_expression (formation) of mitochondrial ROS

1) Confidence 0.08 Published 2006 Journal BMC Cardiovasc Disord Section Body Doc Link PMC1654181 Disease Relevance 0.18 Pain Relevance 0.08

General Comments

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