INT199196

Context Info Confidence 0.26 First Reported 2006 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 2 Total Number 3 Disease Relevance 1.06 Pain Relevance 0.03

mitochondrion (Aldh2) signal transduction (Gnat3) oxidoreductase activity (Aldh2) GTPase activity (Gnat3) cytoplasm (Gnat3) signal transducer activity (Gnat3)

Anatomy Link Frequency heart 1 Gnat3 (Mus musculus) Aldh2 (Mus musculus)

Pain Link Frequency Relevance Heat tolerance 65 56.48 Potency 9 41.64 Bioavailability 1 20.72 alcohol 18 5.00 Angina 11 5.00 agonist 4 5.00 Dopamine 4 5.00 methotrexate 2 5.00 fibrosis 2 5.00 noradrenaline 2 5.00

Disease Link Frequency Relevance Heat Stress 61 98.68 Heart Disease 10 86.20 Cv Unclassified Under Development 30 56.68 Toxicity 18 55.96 Ischemic Heart Disease 6 51.40 Myocardial Infarction 22 40.80 Reprotox - General 2 1 27.72 Targeted Disruption 20 5.00 Cardiovascular Disease 15 5.00 Cv General 3 Under Development 11 5.00

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GTN in vivo treatment decreased the redox-sensitive ALDH-2 activity in isolated heart mitochondria from Mn-SOD+/- mice (30.4 ± 1.5 in ethanol group vs. 21.4 ± 1.5 in GTN group, n = 25–27, p < 0.001) whereas PETN slightly (although not significantly) increased the ALDH-2 activity (39.8 ± 3.3 in DMSO group vs. 42.3 ± 4.4 in PETN group, n = 9, p = 0.647).

GTN Positive_regulation (increased) of ALDH-2 in heart

1) Confidence 0.26 Published 2006 Journal BMC Cardiovasc Disord Section Body Doc Link PMC1654181 Disease Relevance 0.05 Pain Relevance 0.03

Alda-1 increases ALDH2 activity by about two-folds, blocks ALDH2 inactivation by both aldehydes and GTN, and thus increases the cell's natural ability to protect from oxidative stress, leading to 60% reduction from cardiac damage in an animal model of AMI.

GTN Positive_regulation (increases) of ALDH2 associated with stress

2) Confidence 0.12 Published 2010 Journal Cardiovascular Research Section Body Doc Link PMC2936126 Disease Relevance 0.44 Pain Relevance 0

(Right) Agents that increase ALDH2 activity and protect ALDH2 from inactivation by aldehydes and by GTN will decrease the aldehydic load by enhancing the conversion of aldehydes to non-reactive acid (blue cloud in the scheme), thus leading to cytoprotection.

GTN Positive_regulation (increase) of ALDH2

3) Confidence 0.12 Published 2010 Journal Cardiovascular Research Section Body Doc Link PMC2936126 Disease Relevance 0.56 Pain Relevance 0

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