INT199221

Context Info Confidence 0.29 First Reported 2006 Last Reported 2008 Negated 0 Speculated 0 Reported most in Body Documents 2 Total Number 2 Disease Relevance 2.36 Pain Relevance 0.24

cytosol (SAMSN1) nucleus (SAMSN1) cytoplasm (SAMSN1)

Anatomy Link Frequency hepatocytes 1 SAMSN1 (Homo sapiens)

Pain Link Frequency Relevance Heat fibrosis 30 84.32 Inflammation 7 75.88 Pain 1 68.44 alcohol 12 37.72 Paracetamol 4 5.00 Bile 3 5.00 Potency 1 5.00

Disease Link Frequency Relevance Heat Nash(non-alcoholic Steatohepatitis) 100 100.00 Fatty Liver 28 99.28 Hepatitis Virus Infection 3 98.20 Obesity 4 97.60 Diabetes Mellitus 4 97.24 Injury 14 96.92 Insulin Resistance 4 92.24 Pressure And Volume Under Development 4 91.08 Overweight 1 89.72 Fibrosis 25 84.32

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Different studies have shown that factors which are associated with NASH in patients with NAFLD are male gender, age, the extent of obesity, type 2 diabetes, high levels of alanine aminotransferase, aspartate aminotransferase and triglycerides, high HOMA indices of insulin resistance, systemic hypertension, high levels of C-peptide [6,16-21], hyaluronic acid and type VI collagen [22], TNF-alpha and IL-8 [23], and serum acute phase proteins [24].

NASH Binding (associated) of associated with fatty liver, pressure and volume under development, nash(non-alcoholic steatohepatitis), diabetes mellitus, obesity and insulin resistance

1) Confidence 0.29 Published 2006 Journal BMC Gastroenterol Section Body Doc Link PMC1657015 Disease Relevance 1.63 Pain Relevance 0.17

The disappearance of the keratin immunostaining in ballooned hepatocytes is reasonably specific for ASH and NASH, since it is not seen in ballooned cells of viral hepatitis or toxic damage and can therefore be used as an objective morphologic parameter in grading of steatohepatitis (Lackner et al. 2008).

NASH Binding (specific) of in hepatocytes associated with nash(non-alcoholic steatohepatitis) and hepatitis virus infection

2) Confidence 0.02 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2386529 Disease Relevance 0.73 Pain Relevance 0.08

General Comments

This test has worked.