INT199221

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Context Info
Confidence 0.29
First Reported 2006
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 2.36
Pain Relevance 0.24

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (SAMSN1) nucleus (SAMSN1) cytoplasm (SAMSN1)
Anatomy Link Frequency
hepatocytes 1
SAMSN1 (Homo sapiens)
Pain Link Frequency Relevance Heat
fibrosis 30 84.32 Quite High
Inflammation 7 75.88 Quite High
Pain 1 68.44 Quite High
alcohol 12 37.72 Quite Low
Paracetamol 4 5.00 Very Low Very Low Very Low
Bile 3 5.00 Very Low Very Low Very Low
Potency 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Nash(non-alcoholic Steatohepatitis) 100 100.00 Very High Very High Very High
Fatty Liver 28 99.28 Very High Very High Very High
Hepatitis Virus Infection 3 98.20 Very High Very High Very High
Obesity 4 97.60 Very High Very High Very High
Diabetes Mellitus 4 97.24 Very High Very High Very High
Injury 14 96.92 Very High Very High Very High
Insulin Resistance 4 92.24 High High
Pressure And Volume Under Development 4 91.08 High High
Overweight 1 89.72 High High
Fibrosis 25 84.32 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Different studies have shown that factors which are associated with NASH in patients with NAFLD are male gender, age, the extent of obesity, type 2 diabetes, high levels of alanine aminotransferase, aspartate aminotransferase and triglycerides, high HOMA indices of insulin resistance, systemic hypertension, high levels of C-peptide [6,16-21], hyaluronic acid and type VI collagen [22], TNF-alpha and IL-8 [23], and serum acute phase proteins [24].
NASH Binding (associated) of associated with fatty liver, pressure and volume under development, nash(non-alcoholic steatohepatitis), diabetes mellitus, obesity and insulin resistance
1) Confidence 0.29 Published 2006 Journal BMC Gastroenterol Section Body Doc Link PMC1657015 Disease Relevance 1.63 Pain Relevance 0.17
The disappearance of the keratin immunostaining in ballooned hepatocytes is reasonably specific for ASH and NASH, since it is not seen in ballooned cells of viral hepatitis or toxic damage and can therefore be used as an objective morphologic parameter in grading of steatohepatitis (Lackner et al. 2008).
NASH Binding (specific) of in hepatocytes associated with nash(non-alcoholic steatohepatitis) and hepatitis virus infection
2) Confidence 0.02 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2386529 Disease Relevance 0.73 Pain Relevance 0.08

General Comments

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