INT199222

Context Info Confidence 0.57 First Reported 2006 Last Reported 2008 Negated 2 Speculated 0 Reported most in Body Documents 14 Total Number 15 Disease Relevance 18.97 Pain Relevance 1.61

cytosol (SAMSN1) nucleus (SAMSN1) cytoplasm (SAMSN1)

Anatomy Link Frequency hepatocytes 2 liver 2 SAMSN1 (Homo sapiens)

Pain Link Frequency Relevance Heat fibrosis 296 98.64 Paracetamol 12 96.28 alcohol 115 95.72 Inflammation 146 93.84 Inflammatory response 22 78.92 cytokine 42 55.20 Bile 12 14.80 chemokine 12 5.00 Pain 11 5.00 COX2 2 5.00

Disease Link Frequency Relevance Heat Nash(non-alcoholic Steatohepatitis) 1061 100.00 Alcoholic Liver Diseases 95 100.00 Fatty Liver 356 99.98 Hepatitis 233 99.64 Fibrosis 322 98.64 Cirrhosis 161 98.48 Hepatitis Virus Infection 15 98.20 Liver Disease 215 97.86 Disorder Of Lipid Metabolism 55 97.56 Stress 250 96.34

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

However the NAS was intended for use in monitoring changes in liver disease and other clinical situations, and was not intended to replace the pathologist's determination of whether NASH is present or not.

Neg (not) Gene_expression (present) of NASH in liver associated with liver disease and nash(non-alcoholic steatohepatitis)

1) Confidence 0.57 Published 2006 Journal BMC Gastroenterol Section Body Doc Link PMC1657015 Disease Relevance 1.01 Pain Relevance 0.03

In the training group, there was a clinically significant discordance in three patients (2%), all with NT predicting NASH and biopsy showing no NASH.

Gene_expression (biopsy) of NASH associated with nash(non-alcoholic steatohepatitis)

2) Confidence 0.55 Published 2006 Journal BMC Gastroenterol Section Body Doc Link PMC1657015 Disease Relevance 1.28 Pain Relevance 0

Sensitivity analyses revealed that the NT AUROCs for the diagnosis of NASH (Table 6) and the diagnosis of borderline NASH or NASH (Table 7) were not affected by groups, ALT values, alcohol consumption, Gilbert's syndrome, acute inflammation, absence of steatosis, or biopsy sample length.

Gene_expression (diagnosis) of NASH associated with nash(non-alcoholic steatohepatitis), inflammation, syndrome and alcohol

3) Confidence 0.55 Published 2006 Journal BMC Gastroenterol Section Body Doc Link PMC1657015 Disease Relevance 1.34 Pain Relevance 0.09

Unfortunately, many patients with NAFLD or NASH have normal ALT levels and some of them have advanced liver fibrosis [46-48].

Gene_expression (have) of NASH in liver associated with fatty liver, fibrosis, nash(non-alcoholic steatohepatitis) and cirrhosis

4) Confidence 0.55 Published 2006 Journal BMC Gastroenterol Section Body Doc Link PMC1657015 Disease Relevance 1.15 Pain Relevance 0.19

Indeed the value of NT for this diagnostic of NASH was fair (AUROC = 0.80 in the validation group).

Gene_expression (value) of NASH associated with nash(non-alcoholic steatohepatitis)

5) Confidence 0.55 Published 2006 Journal BMC Gastroenterol Section Body Doc Link PMC1657015 Disease Relevance 0.88 Pain Relevance 0

Cases with NAS of 0 to 2 were considered not diagnostic of NASH; on the other hand, cases with scores of 5 or greater were diagnosed as NASH.

Gene_expression (diagnosed) of NASH associated with nash(non-alcoholic steatohepatitis)

6) Confidence 0.55 Published 2006 Journal BMC Gastroenterol Section Body Doc Link PMC1657015 Disease Relevance 1.39 Pain Relevance 0.31

In the training group, there was a clinically significant discordance in three patients (2%), all with NT predicting NASH and biopsy showing no NASH.

Gene_expression (biopsy) of NASH associated with nash(non-alcoholic steatohepatitis)

7) Confidence 0.55 Published 2006 Journal BMC Gastroenterol Section Body Doc Link PMC1657015 Disease Relevance 1.28 Pain Relevance 0

In our NASH population there was a much lower prevalence of cirrhosis, as well as severe steato-hepatitis in comparison with the population of ASH [36].

Gene_expression (population) of NASH associated with nash(non-alcoholic steatohepatitis), cirrhosis and hepatitis

8) Confidence 0.55 Published 2006 Journal BMC Gastroenterol Section Body Doc Link PMC1657015 Disease Relevance 1.95 Pain Relevance 0.03

ROC curves of NT for predicting NASH or borderline NASH are illustrated in Figures 1 to 3.

Gene_expression (predicting) of NASH associated with nash(non-alcoholic steatohepatitis)

9) Confidence 0.55 Published 2006 Journal BMC Gastroenterol Section Body Doc Link PMC1657015 Disease Relevance 1.29 Pain Relevance 0.06

ROC curves of NT for predicting NASH or borderline NASH are illustrated in Figures 1 to 3.

Gene_expression (predicting) of NASH associated with nash(non-alcoholic steatohepatitis)

10) Confidence 0.55 Published 2006 Journal BMC Gastroenterol Section Body Doc Link PMC1657015 Disease Relevance 1.30 Pain Relevance 0.06

The second endpoint was the determination of the pathologist of whether the NASH is present or not.

Neg (not) Gene_expression (present) of NASH associated with nash(non-alcoholic steatohepatitis)

11) Confidence 0.49 Published 2006 Journal BMC Gastroenterol Section Body Doc Link PMC1657015 Disease Relevance 1.36 Pain Relevance 0.29

High levels of intracellular oxidative stress may also be reached within hepatocytes damaged by specific toxins (for example, CCl4 and acetaminophen) or aetiologies (for example, high levels of transition metal ions) or because of individual differences, including induction of peculiar cytochrome P450 isoforms (such as CYP2E1 in ASH/ALD or NASH), antioxidant status or even genetic polymorphisms.

Gene_expression (/) of NASH in hepatocytes associated with stress, nash(non-alcoholic steatohepatitis), paracetamol and alcoholic liver diseases

12) Confidence 0.04 Published 2008 Journal Fibrogenesis Tissue Repair Section Body Doc Link PMC2584013 Disease Relevance 1.49 Pain Relevance 0.24

This suggests that the presence of oxidative stress-triggered immune reactions could be an independent predictor of NAFLD progression to an advanced stage of fibrosis and then, likely, as a mechanism potentially contributing to NAFLD progression to NASH.

Gene_expression (progression) of NASH associated with fatty liver, stress, fibrosis and nash(non-alcoholic steatohepatitis)

13) Confidence 0.04 Published 2008 Journal Fibrogenesis Tissue Repair Section Body Doc Link PMC2584013 Disease Relevance 1.61 Pain Relevance 0.25

The disappearance of the keratin immunostaining in ballooned hepatocytes is reasonably specific for ASH and NASH, since it is not seen in ballooned cells of viral hepatitis or toxic damage and can therefore be used as an objective morphologic parameter in grading of steatohepatitis (Lackner et al. 2008).

Gene_expression (specific) of NASH in hepatocytes associated with nash(non-alcoholic steatohepatitis) and hepatitis virus infection

14) Confidence 0.01 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2386529 Disease Relevance 0.73 Pain Relevance 0.08

MDBs are typical morphological features of ASH and NASH, although NASH usually exhibits slightly less prominent MDBs than the ones seen in ASH (Brunt 2004; Zatloukal et al. 2007).

Gene_expression (features) of NASH associated with nash(non-alcoholic steatohepatitis)

15) Confidence 0.01 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2386529 Disease Relevance 0.88 Pain Relevance 0

General Comments

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