INT199226

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Context Info
Confidence 0.57
First Reported 2006
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 7
Disease Relevance 10.20
Pain Relevance 0.90

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (SAMSN1) nucleus (SAMSN1) cytoplasm (SAMSN1)
Anatomy Link Frequency
hepatocytes 1
liver 1
SAMSN1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Paracetamol 4 97.66 Very High Very High Very High
Inflammation 116 97.04 Very High Very High Very High
fibrosis 148 94.48 High High
Inflammatory response 22 89.44 High High
alcohol 55 73.12 Quite High
cytokine 42 57.96 Quite High
Bile 6 17.56 Low Low
chemokine 12 5.00 Very Low Very Low Very Low
Pain 5 5.00 Very Low Very Low Very Low
COX2 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Nash(non-alcoholic Steatohepatitis) 489 100.00 Very High Very High Very High
Fatty Liver 188 100.00 Very High Very High Very High
Alcoholic Liver Diseases 63 100.00 Very High Very High Very High
Stress 214 99.64 Very High Very High Very High
Disorder Of Lipid Metabolism 25 97.92 Very High Very High Very High
INFLAMMATION 134 97.04 Very High Very High Very High
Liver Disease 131 95.80 Very High Very High Very High
Fibrosis 184 94.48 High High
Hepatitis 107 92.88 High High
Cirrhosis 115 91.44 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The same associations were observed for proteins in univariate analysis with a decrease in ApoA1, haptoglobin and an increase of A2M in NASH.
Positive_regulation (increase) of NASH associated with nash(non-alcoholic steatohepatitis)
1) Confidence 0.57 Published 2006 Journal BMC Gastroenterol Section Body Doc Link PMC1657015 Disease Relevance 1.93 Pain Relevance 0.03
When compared to patients with no NASH, those with NASH or borderline NASH were older, had a higher weight, higher alpha2 macroglobulin, higher ALT and AST, lower GGT, higher glucose higher triglycerides, higher fibrosis stages as assessed by FibroTest and higher steatosis grades as assessed by SteatoTest (Table 2 and Table 3).
Positive_regulation (borderline) of NASH associated with fibrosis and nash(non-alcoholic steatohepatitis)
2) Confidence 0.41 Published 2006 Journal BMC Gastroenterol Section Body Doc Link PMC1657015 Disease Relevance 1.04 Pain Relevance 0.12
Diagnostic values of NT for predicting borderline NASH and NASH in different groups, are given in Table 4 for the concordance with biopsy results, and in Table 5 for sensitivity, specificity and predictive values.
Positive_regulation (borderline) of NASH associated with nash(non-alcoholic steatohepatitis)
3) Confidence 0.41 Published 2006 Journal BMC Gastroenterol Section Body Doc Link PMC1657015 Disease Relevance 1.27 Pain Relevance 0.08
NT AUROCs for the diagnosis of NASH or borderline NASH in NAFLD were unchanged in patients with ALT values lower than 50 IU/L (Table 6 and Table 7); therefore NT could be used to diagnose NASH even in patients that are not eligible for liver biopsy.
Positive_regulation (diagnose) of NASH in liver associated with fatty liver and nash(non-alcoholic steatohepatitis)
4) Confidence 0.41 Published 2006 Journal BMC Gastroenterol Section Body Doc Link PMC1657015 Disease Relevance 1.62 Pain Relevance 0.21
Diagnostic values of NT for predicting borderline NASH and NASH in different groups, are given in Table 4 for the concordance with biopsy results, and in Table 5 for sensitivity, specificity and predictive values.
Positive_regulation (borderline) of NASH associated with nash(non-alcoholic steatohepatitis)
5) Confidence 0.18 Published 2006 Journal BMC Gastroenterol Section Body Doc Link PMC1657015 Disease Relevance 1.28 Pain Relevance 0.08
High levels of intracellular oxidative stress may also be reached within hepatocytes damaged by specific toxins (for example, CCl4 and acetaminophen) or aetiologies (for example, high levels of transition metal ions) or because of individual differences, including induction of peculiar cytochrome P450 isoforms (such as CYP2E1 in ASH/ALD or NASH), antioxidant status or even genetic polymorphisms.
Positive_regulation (induction) of NASH in hepatocytes associated with stress, nash(non-alcoholic steatohepatitis), paracetamol and alcoholic liver diseases
6) Confidence 0.03 Published 2008 Journal Fibrogenesis Tissue Repair Section Body Doc Link PMC2584013 Disease Relevance 1.53 Pain Relevance 0.24
ROS and oxidative stress-related reactive intermediates in NAFLD and NASH: their generation and role in causing steatosis
Positive_regulation (intermediates) of NASH associated with fatty liver, stress and nash(non-alcoholic steatohepatitis)
7) Confidence 0.03 Published 2008 Journal Fibrogenesis Tissue Repair Section Body Doc Link PMC2584013 Disease Relevance 1.53 Pain Relevance 0.14

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