INT19923

Context Info Confidence 0.22 First Reported 1990 Last Reported 2005 Negated 1 Speculated 0 Reported most in Abstract Documents 3 Total Number 3 Disease Relevance 1.10 Pain Relevance 1.25

extracellular space (Ifng) extracellular region (Ifng)

Ifng (Mus musculus)

Pain Link Frequency Relevance Heat cocaine 3 99.12 Morphine 4 97.42 cytokine 8 93.44 Arthritis 1 92.88 methotrexate 5 90.60 dexamethasone 5 90.40 corticosteroid 5 75.00 Inflammation 1 71.84 rheumatoid arthritis 1 69.44 cINOD 1 69.24

Disease Link Frequency Relevance Heat Necrosis 1 100.00 Cancer 1 100.00 Arthritis 4 92.88 Immunization 2 79.32 Candida Infection 2 78.80 INFLAMMATION 3 71.84 Rheumatoid Arthritis 1 69.44 Syndrome 1 33.20 Fever 1 30.72 Headache 1 30.16

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

D-PA failed to influence anti-OVA IgG, IgG2a and IgG1 production as well as IFN-gamma and IL-10 secretion.

Neg (failed) Regulation (influence) of Localization (secretion) of IFN-gamma

1) Confidence 0.22 Published 2005 Journal Int J Immunopathol Pharmacol Section Abstract Doc Link 15698518 Disease Relevance 0.59 Pain Relevance 0.58

In this model, the exposure to morphine (25 mg/kg, 5 days before, during and 5 days after inoculation with the yeast) significant decreased IL-2 and IL-4 levels, while secretion of IFN-gamma was unaltered.

Regulation (unaltered) of Localization (secretion) of IFN-gamma associated with morphine

2) Confidence 0.04 Published 2000 Journal Immunopharmacol Immunotoxicol Section Abstract Doc Link 10737255 Disease Relevance 0.31 Pain Relevance 0.59

A massive and self-limited release of tumor necrosis factor and interferon gamma was detected in the systemic circulation in 35 consecutive renal allograft recipients by specific radioimmunoassays very soon following the first injection of the monoclonal antibody OKT3 (anti-CD3).

Regulation (detected) of Localization (release) of interferon gamma associated with necrosis and cancer

3) Confidence 0.01 Published 1990 Journal Transplantation Section Abstract Doc Link 2109379 Disease Relevance 0.20 Pain Relevance 0.07

General Comments

This test has worked.