INT199257

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Context Info
Confidence 0.18
First Reported 2006
Last Reported 2006
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 6
Disease Relevance 1.14
Pain Relevance 0.40

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
adult brain 1
Tg(Foxn1)E1Hon (Mus musculus)
Pain Link Frequency Relevance Heat
mu opioid receptor 162 90.24 High High
agonist 6 77.64 Quite High
Central nervous system 72 42.84 Quite Low
Morphine 12 36.24 Quite Low
Oxycodone 6 30.36 Quite Low
methadone 6 29.80 Quite Low
Codeine 6 29.36 Quite Low
Analgesic 6 28.44 Quite Low
opioid receptor 12 28.08 Quite Low
Lasting pain 12 23.36 Low Low
Disease Link Frequency Relevance Heat
Targeted Disruption 354 99.32 Very High Very High Very High
Sprains And Strains 6 98.40 Very High Very High Very High
Neuroblastoma 6 81.60 Quite High
Necrosis 6 49.28 Quite Low
Cancer 6 48.92 Quite Low
Congenital Anomalies 6 33.48 Quite Low
Pain 12 23.36 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, all these studies observe an appearance of E1 activity at least 3 days prior to E11 activity.
Positive_regulation (appearance) of E1
1) Confidence 0.18 Published 2006 Journal BMC Mol Biol Section Body Doc Link PMC1657025 Disease Relevance 0.10 Pain Relevance 0
The expression level of the E1/2 transcript at E9.5 and E10.5 was low (0.24~0.31 amole), slowly increased from E11.5 to P0 (1.15~5.30 amole), and reached to highest level in adult (13.48 amole).
Positive_regulation (increased) of E1
2) Confidence 0.18 Published 2006 Journal BMC Mol Biol Section Body Doc Link PMC1657025 Disease Relevance 0.11 Pain Relevance 0
First, the E11 promoter contains a TATA box that is absent in the E1 promoter.
Positive_regulation (absent) of E1
3) Confidence 0.13 Published 2006 Journal BMC Mol Biol Section Body Doc Link PMC1657025 Disease Relevance 0.08 Pain Relevance 0.09
Within numerous putative cis-acting elements predicted from the E1 promoter region by searching transcription factor databases, several cis-acting elements such as a Sp binding sequence, a 34 bp element, a 26 bp polypyrimidine sequence, CRE, OCT1, IL-4-responsive element, NF-?
Positive_regulation (region) of E1
4) Confidence 0.13 Published 2006 Journal BMC Mol Biol Section Body Doc Link PMC1657025 Disease Relevance 0 Pain Relevance 0.31
The expression level of E1/tau transcript between E11.5 and E13.5 was low (0.98~1.36 amole), and gradually increased to higher levels in adult brain (13.19 amole).
Positive_regulation (increased) of E1 in adult brain
5) Confidence 0.12 Published 2006 Journal BMC Mol Biol Section Body Doc Link PMC1657025 Disease Relevance 0.42 Pain Relevance 0
The E1/tau mRNA, which was transcribed through the 8.9 kb E1 promoter in the transgenic construct, was detected at E7.5, which was also two days earlier than the endogenous E1/2 mRNA (E9.5).
Positive_regulation (through) of E1 associated with targeted disruption
6) Confidence 0.11 Published 2006 Journal BMC Mol Biol Section Body Doc Link PMC1657025 Disease Relevance 0.43 Pain Relevance 0

General Comments

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