INT199262

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Context Info
Confidence 0.41
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 4
Disease Relevance 1.19
Pain Relevance 0.40

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Mapt) cytoskeleton (Mapt) nucleus (Mapt)
enzyme binding (Mapt) cytoplasm (Mapt)
Anatomy Link Frequency
cleavage 4
central nervous system 4
Mapt (Mus musculus)
Pain Link Frequency Relevance Heat
Central nervous system 26 99.00 Very High Very High Very High
Enkephalin 4 79.20 Quite High
imagery 24 78.80 Quite High
mu opioid receptor 54 50.00 Quite Low
Thalamus 6 42.08 Quite Low
Substantia nigra 10 41.28 Quite Low
medulla 4 38.72 Quite Low
Spinal cord 20 36.32 Quite Low
Hippocampus 6 5.00 Very Low Very Low Very Low
Lasting pain 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 120 99.68 Very High Very High Very High
Sprains And Strains 4 5.00 Very Low Very Low Very Low
Pain 4 5.00 Very Low Very Low Very Low
Disease 4 5.00 Very Low Very Low Very Low
Neurodegenerative Disease 4 5.00 Very Low Very Low Very Low
Tauopathy 4 5.00 Very Low Very Low Very Low
Neuroblastoma 2 5.00 Very Low Very Low Very Low
Congenital Anomalies 2 5.00 Very Low Very Low Very Low
Necrosis 2 5.00 Very Low Very Low Very Low
Cancer 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We found that the hPSASf dependent cleavage of Tau was not blocked by the aminopeptidase inhibitors bestatin and puromycin, but was inhibited by the metal chelator o-phenanthroline (figure 3).
Negative_regulation (blocked) of Localization (cleavage) of Tau in cleavage
1) Confidence 0.41 Published 2010 Journal Mol Neurodegener Section Body Doc Link PMC2988785 Disease Relevance 0 Pain Relevance 0.07
We found that the hPSASf dependent cleavage of Tau was not blocked by the aminopeptidase inhibitors bestatin and puromycin, but was inhibited by the metal chelator o-phenanthroline (figure 3).
Negative_regulation (inhibited) of Localization (cleavage) of Tau in cleavage
2) Confidence 0.41 Published 2010 Journal Mol Neurodegener Section Body Doc Link PMC2988785 Disease Relevance 0 Pain Relevance 0.08
Distribution of tau/LacZ and tau/GFP reporters in the transgenic mouse central nervous system
Negative_regulation (Distribution) of Localization (reporters) of tau/LacZ in central nervous system associated with targeted disruption and central nervous system
3) Confidence 0.06 Published 2006 Journal BMC Mol Biol Section Body Doc Link PMC1657025 Disease Relevance 0.60 Pain Relevance 0.12
Distribution of tau/LacZ and tau/GFP reporters in the transgenic mouse central nervous system
Negative_regulation (Distribution) of Localization (reporters) of tau/GFP in central nervous system associated with targeted disruption and central nervous system
4) Confidence 0.06 Published 2006 Journal BMC Mol Biol Section Body Doc Link PMC1657025 Disease Relevance 0.60 Pain Relevance 0.12

General Comments

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