INT199265

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Context Info
Confidence 0.67
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 1.34
Pain Relevance 0.34

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Mapt) cytoskeleton (Mapt) nucleus (Mapt)
enzyme binding (Mapt) cytoplasm (Mapt)
Anatomy Link Frequency
medial cerebellar nucleus 2
Mapt (Mus musculus)
Pain Link Frequency Relevance Heat
Central nervous system 13 98.28 Very High Very High Very High
Substantia nigra 5 88.72 High High
Hippocampus 4 87.12 High High
Pyramidal cell 1 82.40 Quite High
Spinal cord 10 68.20 Quite High
medulla 2 66.92 Quite High
Thalamus 3 65.20 Quite High
mu opioid receptor 27 50.00 Quite Low
imagery 12 5.00 Very Low Very Low Very Low
Eae 10 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 30 95.48 Very High Very High Very High
Targeted Disruption 83 90.96 High High
Apoptosis 6 85.12 High High
Urological Neuroanatomy 1 84.16 Quite High
Shock 1 79.36 Quite High
Neurodegenerative Disease 5 78.72 Quite High
Dementia 3 75.96 Quite High
Cognitive Disorder 3 73.80 Quite High
Amyloid Plaque 3 71.20 Quite High
Alzheimer's Dementia 8 50.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To this end, we have crossed our AID lines with hTau mice [29], [30] overexpressing human Tau.
Positive_regulation (overexpressing) of Gene_expression (overexpressing) of Tau
1) Confidence 0.67 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2905372 Disease Relevance 1.21 Pain Relevance 0.04
The expressed PSA had no effect of the intracellular level of Tau under steady-state expression conditions (figure 6A) or when Tau expression was induced (figure 6B).
Positive_regulation (induced) of Gene_expression (expression) of Tau
2) Confidence 0.67 Published 2010 Journal Mol Neurodegener Section Body Doc Link PMC2988785 Disease Relevance 0.08 Pain Relevance 0
Interestingly, both tau/LacZ and tau/GFP expression were quite prominent in Purkinje cells and in the medial cerebellar nucleus, suggesting potential roles in motor actions (Fig. 5Q–T).
Positive_regulation (prominent) of Gene_expression (expression) of tau/GFP in medial cerebellar nucleus
3) Confidence 0.06 Published 2006 Journal BMC Mol Biol Section Body Doc Link PMC1657025 Disease Relevance 0.05 Pain Relevance 0.30

General Comments

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