INT199276

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.46
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 12
Total Number 12
Disease Relevance 2.67
Pain Relevance 0.24

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Tbp) DNA binding (Tbp) transcription factor binding (Tbp)
cytoplasm (Tbp)
Anatomy Link Frequency
proximal 3
Tbp (Mus musculus)
Pain Link Frequency Relevance Heat
mu opioid receptor 27 83.72 Quite High
addiction 30 68.96 Quite High
fluoxetine 20 58.24 Quite High
Central nervous system 12 5.00 Very Low Very Low Very Low
imagery 11 5.00 Very Low Very Low Very Low
Spinal cord 10 5.00 Very Low Very Low Very Low
Substantia nigra 5 5.00 Very Low Very Low Very Low
Thalamus 3 5.00 Very Low Very Low Very Low
Hippocampus 3 5.00 Very Low Very Low Very Low
Lasting pain 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Dementia 10 99.92 Very High Very High Very High
Tremor 10 99.40 Very High Very High Very High
Neuroblastoma 12 96.96 Very High Very High Very High
Disease 51 93.40 High High
Death 110 86.68 High High
Apoptosis 150 86.56 High High
Spinocerebellar Ataxia Type 2 10 80.92 Quite High
Neurodegenerative Disease 50 76.00 Quite High
Necrosis 1 64.64 Quite High
Cancer 69 64.28 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It has been shown that many gene specific transcription factors exert their effects by directly or indirectly interacting with TBP and stabilizing TBP-TATA box interaction at the proximal promoter region [13], [14].
TBP Binding (interaction) of in proximal
1) Confidence 0.46 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2064964 Disease Relevance 0 Pain Relevance 0
It has been shown that many gene specific transcription factors exert their effects by directly or indirectly interacting with TBP and stabilizing TBP-TATA box interaction at the proximal promoter region [13], [14].
TBP Binding (interacting) of in proximal
2) Confidence 0.46 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2064964 Disease Relevance 0 Pain Relevance 0
Even at TATA box containing promoters, TBP binds inefficiently in the presence of chromatin and requires gene specific trans-activators [13].
TBP Binding (binds) of
3) Confidence 0.46 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2064964 Disease Relevance 0.44 Pain Relevance 0
The conserved C-terminal domain of TBP is sufficient for binding to the TATA box and can be co-crystalized with it [24].
TBP Binding (binding) of
4) Confidence 0.46 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2064964 Disease Relevance 0.05 Pain Relevance 0
Expansion of polyQ and formation of TBP containing protein aggregates suggest that TBP can cause enhanced expression of a downstream gene by titrating away a gene specific repressor.
TBP Binding (formation) of
5) Confidence 0.35 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2064964 Disease Relevance 0.38 Pain Relevance 0
We find that TBP occupancy at the promoter of upregulated genes was elevated irrespective of the presence of the TATA box.
TBP Binding (occupancy) of
6) Confidence 0.34 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2064964 Disease Relevance 0.42 Pain Relevance 0
Using an artificially tethered TBP with promoter-reporter fusions and at the genome-wide level it has been shown that many gene specific transcription factors exert their effects by directly or indirectly interacting with TBP and stabilizing TBP-TATA box interaction at the proximal promoter region [13], [14].
TBP Binding (interaction) of in proximal
7) Confidence 0.34 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2064964 Disease Relevance 0.05 Pain Relevance 0.12
Chromatin Immunoprecipitation studies at a TATA containing and a TATA less promoter from the differentially expressed genes suggested that TBP occupancy was elevated in vivo.
TBP Binding (occupancy) of
8) Confidence 0.34 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2064964 Disease Relevance 0.49 Pain Relevance 0
We used anti-TBP antibody rather than the 1C2 antibody against polyQ as 1C2 antibody interacts with polyQ stretches in other transcription factors also and anti-TBP antibody recognizes TBP expressed from the endogenous gene as well as transfected gene.
TBP Binding (recognizes) of
9) Confidence 0.34 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2064964 Disease Relevance 0.05 Pain Relevance 0
TBP a general transcription factor for a majority of eukaryotic promoters, binds to the core promoter element, TATA box (TAT/AAAT) upstream of transcription start site and initiates transcription by allowing assembly of pre-initiation complex [6], [7].
TBP Binding (binds) of
10) Confidence 0.30 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2064964 Disease Relevance 0.55 Pain Relevance 0
The basal core region contains a TATA box that can specifically bind to a TATA-binding protein (TBP) in a gel shifting assay[43].
TBP Binding (bind) of
11) Confidence 0.19 Published 2006 Journal BMC Mol Biol Section Body Doc Link PMC1657025 Disease Relevance 0.23 Pain Relevance 0.11
Quantifications were normalized to corresponding RNA L32 and TBP values.
TBP Binding (normalized) of
12) Confidence 0.11 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2840030 Disease Relevance 0 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox