INT199287

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Context Info
Confidence 0.02
First Reported 2005
Last Reported 2006
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 1.86
Pain Relevance 1.80

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (TNF, Oprm1) plasma membrane (TNF, Oprm1) extracellular space (TNF)
extracellular region (TNF) intracellular (TNF) extracellular matrix organization (TNF)
Anatomy Link Frequency
immune cells 2
TNF (Homo sapiens)
Oprm1 (Mus musculus)
Pain Link Frequency Relevance Heat
mu opioid receptor 27 100.00 Very High Very High Very High
cytokine 14 99.98 Very High Very High Very High
Morphine 38 90.48 High High
Nerve growth factor 10 90.08 High High
Analgesic 33 89.60 High High
midbrain 4 86.96 High High
Inflammation 130 83.60 Quite High
opioid receptor 190 79.60 Quite High
dorsal root ganglion 22 68.08 Quite High
Spinal cord 32 56.24 Quite High
Disease Link Frequency Relevance Heat
Cancer 7 100.00 Very High Very High Very High
Necrosis 5 100.00 Very High Very High Very High
Targeted Disruption 65 84.24 Quite High
INFLAMMATION 140 83.60 Quite High
Neuroblastoma 3 72.28 Quite High
Ganglion Cysts 24 68.08 Quite High
Nociception 18 63.60 Quite High
Pain 76 50.00 Quite Low
Neuropathic Pain 10 47.76 Quite Low
Osteoarthritis 2 14.92 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Tumor necrosis factor can induce the mu opioid receptor gene transcription in several types of immune cells.
Tumor necrosis factor Positive_regulation (induce) of Transcription (transcription) of mu opioid receptor gene in immune cells associated with necrosis, cancer and mu opioid receptor
1) Confidence 0.02 Published 2006 Journal BMC Mol Biol Section Body Doc Link PMC1657025 Disease Relevance 0.20 Pain Relevance 0.15
Furthermore, the proinflammatory cytokine tumor necrosis factor (TNF) induces MOR gene transcription, via the transcription factor nuclear factor ?
tumor necrosis factor Positive_regulation (induces) of Transcription (transcription) of MOR gene associated with necrosis, cancer and cytokine
2) Confidence 0.01 Published 2005 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC1661636 Disease Relevance 0.83 Pain Relevance 0.83
Furthermore, the proinflammatory cytokine tumor necrosis factor (TNF) induces MOR gene transcription, via the transcription factor nuclear factor ?
TNF Positive_regulation (induces) of Transcription (transcription) of MOR gene associated with necrosis, cancer and cytokine
3) Confidence 0.01 Published 2005 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC1661636 Disease Relevance 0.83 Pain Relevance 0.82

General Comments

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