INT19929

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Context Info
Confidence 0.59
First Reported 1990
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 52
Total Number 53
Disease Relevance 38.16
Pain Relevance 16.51

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (TNF) extracellular space (TNF) extracellular region (TNF)
plasma membrane (TNF) intracellular (TNF) extracellular matrix organization (TNF)
Anatomy Link Frequency
macrophages 8
brain 4
T cell 4
optic nerve 3
plasma 2
TNF (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 588 100.00 Very High Very High Very High
cytokine 409 100.00 Very High Very High Very High
Pain 139 100.00 Very High Very High Very High
Inflammatory mediators 27 100.00 Very High Very High Very High
Analgesic 5 99.98 Very High Very High Very High
addiction 5 99.90 Very High Very High Very High
rheumatoid arthritis 219 99.88 Very High Very High Very High
Intracerebroventricular 3 99.84 Very High Very High Very High
Endep 3 99.66 Very High Very High Very High
cINOD 49 99.60 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 658 100.00 Very High Very High Very High
Cancer 321 100.00 Very High Very High Very High
Pain 146 100.00 Very High Very High Very High
Necrosis 87 100.00 Very High Very High Very High
Osteoporosis 49 100.00 Very High Very High Very High
Nervous System Injury 5 100.00 Very High Very High Very High
Drug Dependence 1 99.90 Very High Very High Very High
Rheumatoid Arthritis 329 99.88 Very High Very High Very High
Pulmonary Disease 280 99.80 Very High Very High Very High
Stress 66 99.52 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Exogenous prostaglandin E(2) (IC(50)<5 nM) inhibited endotoxin-induced TNFalpha mRNA and protein while, up to 1 microM, it did not significantly affect cyclooxygenase-2 mRNA expression.
Negative_regulation (inhibited) of Positive_regulation (induced) of TNFalpha
1) Confidence 0.59 Published 2004 Journal Eur. J. Pharmacol. Section Abstract Doc Link 15464057 Disease Relevance 0.19 Pain Relevance 0.16
Systemic administration of iloprost inhibited serum TNF levels after intraperitoneal LPS, whereas intracerebroventricular injection of iloprost or PGE2 did not inhibit brain TNF induced by intracerebroventricular LPS.
Negative_regulation (inhibit) of Positive_regulation (induced) of TNF in brain associated with intracerebroventricular
2) Confidence 0.58 Published 1998 Journal J. Neurochem. Section Abstract Doc Link 9798931 Disease Relevance 0.67 Pain Relevance 0.69
We also observed a significant reduction in the induction of both TNF-?
Negative_regulation (reduction) of Positive_regulation (induction) of TNF
3) Confidence 0.57 Published 2010 Journal Journal of Neuroinflammation Section Body Doc Link PMC3022819 Disease Relevance 0.19 Pain Relevance 0.03
Treatment of these two HA preparations with deoxyribonuclease I abrogated or reduced the induction of IL-12 and TNF-alpha.
Negative_regulation (reduced) of Positive_regulation (induction) of TNF-alpha
4) Confidence 0.52 Published 2001 Journal J. Pharm. Pharmacol. Section Abstract Doc Link 11341374 Disease Relevance 0.73 Pain Relevance 0.50
These in vivo results suggest that shikonins inhibit the transcriptional activation of the human TNF-alpha promoter through interference with the basal transcription machinery.
Negative_regulation (inhibit) of Positive_regulation (activation) of TNF-alpha
5) Confidence 0.51 Published 2004 Journal J. Biol. Chem. Section Abstract Doc Link 14645256 Disease Relevance 0.28 Pain Relevance 0.07
Consistent with downregulation of bone-resorbing mediators, eugenol suppressed the messenger RNA expression of LPS-induced IL-1beta, TNF-alpha, and cyclooxygenase-2 in macrophages.
Negative_regulation (suppressed) of Positive_regulation (induced) of TNF-alpha in macrophages
6) Confidence 0.43 Published 2007 Journal J Endod Section Abstract Doc Link 17509409 Disease Relevance 0.33 Pain Relevance 0.23
RA sera inhibit T cell-dependent TNF-?
Negative_regulation (inhibit) of Positive_regulation (dependent) of TNF in T cell associated with rheumatoid arthritis
7) Confidence 0.42 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1297564 Disease Relevance 0.86 Pain Relevance 0.43
In addition, treatment with HA partially blocked LPS (1 ng/ml) induced TNF?
Negative_regulation (blocked) of Positive_regulation (induced) of TNF
8) Confidence 0.42 Published 2007 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2695202 Disease Relevance 0.94 Pain Relevance 0.12
In addition, sodium salicylate and additional NSAIDs used at concentrations that activate HSF1 also inhibited the expression of other monocytic genes (TNF-alpha, IL-1beta, IL-6, IL-8, IL-10, ICAM-1) activated by exposure to a pro-inflammatory stimulus (lipopolysaccharide, LPS).
Negative_regulation (inhibited) of Positive_regulation (activated) of TNF-alpha associated with cinod and inflammatory stimuli
9) Confidence 0.42 Published 1999 Journal Cytokine Section Abstract Doc Link 10328874 Disease Relevance 0.74 Pain Relevance 0.81
2-agonist and an inhaled corticosteroid can influence both airway obstruction (smooth muscle contraction, increased cholinergic tone, and loss of elastic recoil), and airway inflammation (increased numbers of neutrophils, macrophages and CD8+lymphocytes, elevated IL-8 and TNF-a, and protease┬ľantiprotease imbalance) (Cazzola and Dahl 2004; Cazzola et al 2004).
Negative_regulation (numbers) of Positive_regulation (increased) of TNF-a in lymphocytes associated with corticosteroid, inflammation, airway obstruction and agonist
10) Confidence 0.42 Published 2006 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2706613 Disease Relevance 0.42 Pain Relevance 0.15
In contrast, we observed that neither type of TDM repressed the LPS-induced TNF-?
Negative_regulation (repressed) of Positive_regulation (induced) of TNF
11) Confidence 0.41 Published 2008 Journal PLoS Pathogens Section Body Doc Link PMC2390761 Disease Relevance 0.29 Pain Relevance 0.10
It was noted that a few rats developed increased TNF?
Negative_regulation (developed) of Positive_regulation (increased) of TNF
12) Confidence 0.41 Published 2007 Journal J Inflamm (Lond) Section Body Doc Link PMC1919375 Disease Relevance 0.29 Pain Relevance 0.14
The decline in ovarian function is associated with decreased OPG production and spontaneous increases in proinflammatory and pro-osteoclastic cytokines such as IL-6, TNF-?
Negative_regulation (decreased) of Positive_regulation (increases) of TNF associated with osteoporosis and cytokine
13) Confidence 0.41 Published 2005 Journal Immun Ageing Section Body Doc Link PMC1308846 Disease Relevance 0.90 Pain Relevance 0.19
Testosterone replacement therapy has also been shown to reduce circulating levels of inflammatory mediators, such as TNF-?
Negative_regulation (reduce) of Positive_regulation (circulating) of TNF associated with inflammatory mediators
14) Confidence 0.41 Published 2006 Journal BMC Cardiovasc Disord Section Body Doc Link PMC1693568 Disease Relevance 1.40 Pain Relevance 0.09
ApoA-I bound the stimulating factor at the surface of T lymphocytes, hampered the binding of stimulated T lymphocytes with its specific receptor at monocyte surface, thus inhibited the production of pro-inflammatory cytokines including TNF-?
Negative_regulation (inhibited) of Positive_regulation (cytokines) of TNF in T lymphocytes associated with inflammation and cytokine
15) Confidence 0.41 Published 2010 Journal Lipids Health Dis Section Body Doc Link PMC2860353 Disease Relevance 1.99 Pain Relevance 0.72
Pentoxifylline, which reduces the production of inflammatory cytokines like TNF-?
Negative_regulation (reduces) of Positive_regulation (cytokines) of TNF associated with inflammation and cytokine
16) Confidence 0.40 Published 2009 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2697543 Disease Relevance 1.11 Pain Relevance 0.20
Tumor necrosis factor-alpha (TNF) is upregulated after nerve injury, causes pain on injection, and its blockade reduces pain behavior resulting from nerve injury; thus it is strongly implicated in neuropathic pain.
Negative_regulation (reduces) of Positive_regulation (upregulated) of TNF in nerve associated with pain, necrosis, nervous system injury, cancer and neuropathic pain
17) Confidence 0.40 Published 2003 Journal J. Neurosci. Section Abstract Doc Link 12684490 Disease Relevance 1.06 Pain Relevance 0.73
Amitriptyline as an analgesic inhibits pain-induced increases in brain-associated TNF and transforms peripheral alpha(2)-adrenergic receptors.
Negative_regulation (inhibits) of Positive_regulation (increases) of TNF in brain associated with pain, analgesic and endep
18) Confidence 0.39 Published 2007 Journal Brain Behav. Immun. Section Abstract Doc Link 16859892 Disease Relevance 0.73 Pain Relevance 0.98
The finding that LSS-dependent reduction of TNF-alpha generation and HO-1 induction were abrogated by the selective inhibitor of COX-2 NS-398, the nonselective COX inhibitor aspirin, or the specific prostacyclin receptor (IP) antagonist RO3244794 illuminates the central role played by LSS-induced COX-2-dependent prostacyclin in restraining endothelial inflammation.
Negative_regulation (abrogated) of Positive_regulation (induction) of TNF-alpha associated with stress, aspirin, inflammation and antagonist
19) Confidence 0.38 Published 2009 Journal Circ. Res. Section Abstract Doc Link 19122175 Disease Relevance 1.08 Pain Relevance 0.21
Immunosuppressive drug addiction can reduce the induction of anti-TNF-alpha antibodies.
Negative_regulation (reduce) of Positive_regulation (induction) of anti-TNF-alpha associated with drug dependence and addiction
20) Confidence 0.37 Published 2010 Journal Clin Rev Allergy Immunol Section Abstract Doc Link 19565360 Disease Relevance 0.84 Pain Relevance 0.62

General Comments

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