INT199308

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.75
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 37
Total Number 38
Disease Relevance 23.17
Pain Relevance 1.06

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

structural molecule activity (Krt8) nucleus (Krt8) cytoplasm (Krt8)
Anatomy Link Frequency
liver 5
hepatocytes 3
epithelial cells 3
lung 1
Krt8 (Mus musculus)
Krt8 - G61C (1)
Pain Link Frequency Relevance Heat
Paracetamol 100 98.60 Very High Very High Very High
fibrosis 203 89.60 High High
Potency 25 85.04 High High
Bile 75 84.32 Quite High
bDMF 49 82.92 Quite High
imagery 35 73.60 Quite High
Inflammation 111 70.16 Quite High
alcohol 76 66.00 Quite High
antagonist 8 5.00 Very Low Very Low Very Low
cINOD 7 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Carcinoma 69 99.98 Very High Very High Very High
Targeted Disruption 400 99.90 Very High Very High Very High
Cancer 1170 99.48 Very High Very High Very High
Liver Disease 375 99.40 Very High Very High Very High
Ovarian Cancer 206 99.38 Very High Very High Very High
Death 66 99.04 Very High Very High Very High
Ovarian Diseases 6 98.76 Very High Very High Very High
Stress 450 98.24 Very High Very High Very High
Hepatotoxicity 50 97.72 Very High Very High Very High
Aging 50 97.68 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Tumors grown from transplanted G-2 cells (Figure 5A) recapitulated the distinctive features of high-grade WAP-T tumors (Figure 5B), namely a moderate proportion of cells co-expressing Krt14 and Krt8/18.
Gene_expression (expressing) of Krt8 associated with cancer
1) Confidence 0.75 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2920333 Disease Relevance 1.66 Pain Relevance 0
Immunostaining analysis of vimentin and Krt8/18 expression in G-2 cell derived tumors (Figure 3A) revealed their close resemblance to poorly differentiated (grade G3) WAP-T tumors (Figure 3B).
Gene_expression (expression) of Krt8 associated with cancer
2) Confidence 0.75 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2920333 Disease Relevance 0.93 Pain Relevance 0
Stronger expression of Krt7 is observed in TOV-1946 and TOV-2223G was the only cell line that expressed Krt18 and Krt8.
Gene_expression (expressed) of Krt8
3) Confidence 0.66 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2467432 Disease Relevance 0.95 Pain Relevance 0
In order to determine if our cell lines presented these EOC markers, we monitored protein expression of Krt7, Krt8 and Krt18 by western blot.
Gene_expression (expression) of Krt8 associated with ovarian cancer
4) Confidence 0.66 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2467432 Disease Relevance 0.78 Pain Relevance 0
The epithelial characteristics of the cell lines were also verified by the expression of Krt18 and Krt8, which are also markers of epithelial cells.
Gene_expression (expression) of Krt8 in epithelial cells
5) Confidence 0.66 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2467432 Disease Relevance 0.93 Pain Relevance 0
Both OSE and EOC tumors are characterized by the expression of different keratins such as KRT7, KRT8 and KRT18.
Gene_expression (expression) of KRT8 associated with cancer and ovarian cancer
6) Confidence 0.66 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2467432 Disease Relevance 0.80 Pain Relevance 0
In this respect, it is likely that the pronounced co-expression of Krt14 and Krt8/18 proteins in G-2 culture, but not in G-2 tumors, is attributed to selection in cell culture for a pro-proliferative function of Krt14.
Gene_expression (expression) of Krt8 associated with cancer
7) Confidence 0.58 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2920333 Disease Relevance 0.63 Pain Relevance 0
Griseofulvin/DDC feeding leads to rapid induction of K8/K18 expression with disproportional K8 > K18 levels (Denk et al. 2000).
Gene_expression (expression) of K8
8) Confidence 0.50 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2386529 Disease Relevance 0.71 Pain Relevance 0
Keratins are major constituents of MDBs and both altered K8/K18 expression and keratin modification seems to affect MDB formation (Zatloukal et al. 2007; Ku et al. 2007).
Gene_expression (expression) of K8
9) Confidence 0.50 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2386529 Disease Relevance 0.78 Pain Relevance 0
MDBs also arise in cell culture after transfection with K8/K18, ubiquitin, and p62.
Gene_expression (transfection) of K8
10) Confidence 0.50 Published 2008 Journal Histochem Cell Biol Section Abstract Doc Link PMC2386529 Disease Relevance 1.00 Pain Relevance 0.04
However, one important caveat is the fact, that K8/K18/K19 are expressed in most simple epithelial cells and are therefore not liver-specific (Moll et al. 1982; Ku et al. 1999).
Gene_expression (expressed) of K8 in liver
11) Confidence 0.50 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2386529 Disease Relevance 0.31 Pain Relevance 0
Dysbalanced K8/K18 expression precedes MDB formation, likely increases keratin misfolding and predisposes to posttranslational modifications, which may interfere with keratin refolding and/or repair.
Gene_expression (expression) of K8
12) Confidence 0.50 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2386529 Disease Relevance 0.30 Pain Relevance 0
In addition, transgenic mice over-expressing K8 R340 variants displayed augmented acetaminophen-induced liver toxicity.
Gene_expression (expressing) of K8 in liver associated with targeted disruption, paracetamol and hepatotoxicity
13) Confidence 0.50 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2386529 Disease Relevance 1.25 Pain Relevance 0.34
The recently established transgenic mouse lines overexpressing the naturally occurring K8 G61C and R340H variants will likely offer valuable insights in this respect (Ku and Omary 2006; Zhou et al., unpublished data).


Gene_expression (overexpressing) of K8 G61C (G61C) associated with targeted disruption
14) Confidence 0.50 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2386529 Disease Relevance 0.79 Pain Relevance 0.11
This is supported by studies in transgenic mice, where K8 overexpression accelerates and K18 excess inhibits not only MDB, but also cross-link formation (Strnad et al. 2007).
Gene_expression (overexpression) of K8 associated with targeted disruption
15) Confidence 0.50 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2386529 Disease Relevance 0.20 Pain Relevance 0
For example, a low percentage of hepatocytes express keratin 7 and to a lesser extent keratin 19 which indicate that these cells acquire features of precursor cells which normally express keratin 8, 18, 7, and 19 during regeneration (Van Eyken et al. 1988; Zatloukal et al. 2004).
Gene_expression (express) of keratin 8 in hepatocytes
16) Confidence 0.43 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2386529 Disease Relevance 0.50 Pain Relevance 0
In cell culture experiments, protein aggregates resembling MDBs formed only after p62 co-transfection, but not when K8, K18, and ubiquitin were transfected alone or in combination (Stumptner et al. 2007).
Gene_expression (transfected) of K8
17) Confidence 0.43 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2386529 Disease Relevance 0.17 Pain Relevance 0
Furthermore, autophagic degradation is upregulated in DDC-fed mice and its further stimulation with rapamycin attenuates spontaneous MDB formation in K8 overexpressing mice (Harada et al. 2008).
Gene_expression (overexpressing) of K8
18) Confidence 0.43 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2386529 Disease Relevance 0.14 Pain Relevance 0.03
Adult hepatocytes are unique among simple epithelial cells in that they express exclusively K8 and K18, whereas other glandular epithelia exhibit a more complex keratin expression pattern (Omary et al. 2002; Ku et al. 2007).
Gene_expression (express) of K8 in hepatocytes
19) Confidence 0.43 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2386529 Disease Relevance 0.65 Pain Relevance 0.04
Several pathogenic mechanisms were implicated in this process (Fig. 4; Dobson 2004):1.Enhanced oxidative stress2.Disproportional K8/K18 expression together with keratin modifications3.Chaperone dysfunction4.Elevated p62 levels5.Insufficient protein degradation
Gene_expression (expression) of K8
20) Confidence 0.43 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2386529 Disease Relevance 0.22 Pain Relevance 0.08

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox