INT199315

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Context Info
Confidence 0.34
First Reported 2006
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 8
Total Number 9
Disease Relevance 7.02
Pain Relevance 1.14

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Plat) extracellular space (Plat) extracellular region (Plat)
cytoplasm (Plat)
Anatomy Link Frequency
plaque 2
Plat (Mus musculus)
Pain Link Frequency Relevance Heat
aspirin 10 99.80 Very High Very High Very High
ischemia 63 96.12 Very High Very High Very High
Inflammation 33 94.64 High High
cva 29 93.76 High High
cytokine 12 85.36 High High
Eae 1 83.12 Quite High
imagery 76 70.40 Quite High
Inflammatory response 1 44.24 Quite Low
Central nervous system 18 5.00 Very Low Very Low Very Low
metalloproteinase 14 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Diabetes Mellitus 188 99.76 Very High Very High Very High
Carotid Stenosis 84 99.38 Very High Very High Very High
Reperfusion Injury 5 97.92 Very High Very High Very High
Injury 14 96.68 Very High Very High Very High
Cv Unclassified Under Development 51 96.12 Very High Very High Very High
Brain Injury 5 96.08 Very High Very High Very High
Increased Venous Pressure Under Development 6 95.08 Very High Very High Very High
INFLAMMATION 33 94.64 High High
Encephalitis 1 94.60 High High
Cv General 4 Under Development 10 93.76 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Active mouse tPA binds to the biotinylated human PAI-1 coated on a microtiter, and an ELISA kit can be used to measure the active tPA in conditioned media.
tPA Binding (binds) of
1) Confidence 0.34 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2815778 Disease Relevance 0 Pain Relevance 0
ANOVA analyses indicated that transformed IMT was significantly associated with age (p < .001), diastolic BP (p < .01) and Framingham score (p < .05) for the diabetic population and TPV and TPA were both significantly associated with age (p < .001), diabetes (p < .001), presence of plaque ulcerations (p < .01) and Framingham score (p < .01).
TPA Binding (associated) of in plaque associated with diabetes mellitus
2) Confidence 0.32 Published 2006 Journal Cardiovasc Ultrasound Section Body Doc Link PMC1657034 Disease Relevance 0.86 Pain Relevance 0
Moreover, for the diabetic population, only TPA and TPV were significantly associated with diabetes type, and not IMT.
TPA Binding (associated) of associated with diabetes mellitus
3) Confidence 0.32 Published 2006 Journal Cardiovasc Ultrasound Section Body Doc Link PMC1657034 Disease Relevance 1.09 Pain Relevance 0.07
The same analysis of the carotid stenosis population revealed that both TPA and TPV were significantly associated with sex (p < .001) and presence of ulcerations (p < .01).
TPA Binding (associated) of associated with carotid stenosis
4) Confidence 0.32 Published 2006 Journal Cardiovasc Ultrasound Section Body Doc Link PMC1657034 Disease Relevance 1.06 Pain Relevance 0
Differences were observed as well in that TPA and TPV in both populations were associated with ulcerations, whereas IMT was not associated with plaque ulcerations for the diabetic population where IMT was measured.
TPA Binding (associated) of in plaque associated with diabetes mellitus
5) Confidence 0.32 Published 2006 Journal Cardiovasc Ultrasound Section Body Doc Link PMC1657034 Disease Relevance 1.18 Pain Relevance 0.03
The concentrations of the primary antibodies employed were: tPA (1?
tPA Binding (were) of
6) Confidence 0.31 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2815778 Disease Relevance 0 Pain Relevance 0
tPA alone significantly decreased mortality at 7 days after MCAO, but combination therapy with tPA plus cilostazol did not improve the mortality more than tPA alone (?
tPA Binding (therapy) of
7) Confidence 0.30 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2997776 Disease Relevance 0.78 Pain Relevance 0.20
Therefore, we tested whether a combination of t-PA and ASA confers additional neuroprotection against reperfusion damage by treatment at 3 h after ischemia.
t-PA Spec (whether) Binding (combination) of associated with aspirin, reperfusion injury and ischemia
8) Confidence 0.13 Published 2010 Journal Naunyn Schmiedebergs Arch Pharmacol Section Body Doc Link PMC2926440 Disease Relevance 1.48 Pain Relevance 0.67
TPA can also directly bind to PKC; members of the PKC family regulate downstream of nearly all membrane-associated signal transduction pathways.
TPA Binding (bind) of
9) Confidence 0.06 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2668769 Disease Relevance 0.57 Pain Relevance 0.17

General Comments

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