INT199330

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Context Info
Confidence 0.57
First Reported 2006
Last Reported 2008
Negated 1
Speculated 0
Reported most in Body
Documents 3
Total Number 6
Disease Relevance 3.12
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lyase activity (Pck1) nucleus (Pck1) kinase activity (Pck1)
lipid metabolic process (Pck1) cytoplasm (Pck1)
Anatomy Link Frequency
hepatocyte 1
liver 1
colon 1
adipose tissue 1
Pck1 (Mus musculus)
Pain Link Frequency Relevance Heat
tolerance 43 38.68 Quite Low
anesthesia 6 5.00 Very Low Very Low Very Low
agonist 4 5.00 Very Low Very Low Very Low
Kinase C 4 5.00 Very Low Very Low Very Low
Immobilon 4 5.00 Very Low Very Low Very Low
imagery 4 5.00 Very Low Very Low Very Low
cytokine 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hyperglycemia 10 99.56 Very High Very High Very High
Obesity 34 97.84 Very High Very High Very High
Targeted Disruption 120 97.40 Very High Very High Very High
Diabetes Mellitus 86 93.48 High High
Insulin Resistance 69 89.12 High High
Metastasis 2 84.76 Quite High
Cancer 95 77.56 Quite High
Apoptosis 15 74.56 Quite High
Carcinoma 3 65.84 Quite High
Adenoma 36 65.24 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Also, PEPCK gene modulation in the liver has resulted in remarkable effects on systemic glucose metabolism in mice.
Regulation (modulation) of PEPCK in liver
1) Confidence 0.57 Published 2008 Journal Diabetes Section Body Doc Link PMC2494684 Disease Relevance 0.80 Pain Relevance 0
The regulation of gluconeogenesis predominantly depends on the expression level of gluconeogenic genes such as PEPCK and G6Pase (31,32).
Regulation (regulation) of PEPCK
2) Confidence 0.47 Published 2008 Journal Diabetes Section Body Doc Link PMC2494675 Disease Relevance 0.59 Pain Relevance 0
Glucose-6-phosphatase and PEPCK-C are regulated by transcription factors like hepatocyte nuclear factor-4?
Regulation (regulated) of PEPCK in hepatocyte
3) Confidence 0.25 Published 2008 Journal Diabetes Section Body Doc Link PMC2494684 Disease Relevance 0.17 Pain Relevance 0
No changes in PEPCK-C protein content were observed either in kidney or epididymal adipose tissue (Fig. 1C and D).
Neg (No) Regulation (changes) of PEPCK in adipose tissue associated with obesity
4) Confidence 0.25 Published 2008 Journal Diabetes Section Body Doc Link PMC2494684 Disease Relevance 0.20 Pain Relevance 0
Long- and medium-chain fatty acid oxidation are highly regulated through PEPCK-C import into the mitochondria at the level of CPT-1.
Regulation (regulated) of PEPCK
5) Confidence 0.25 Published 2008 Journal Diabetes Section Body Doc Link PMC2494684 Disease Relevance 0.26 Pain Relevance 0
Female NMRI mice, overexpressing human IGF-II under the control of the rat phosphoenolpyruvate carboxykinase (PEPCK) promoter in several tissues including colon [24] and their non-transgenic female NMRI littermates were used in this study.
Regulation (control) of PEPCK in colon associated with targeted disruption
6) Confidence 0.12 Published 2006 Journal J Carcinog Section Body Doc Link PMC1660565 Disease Relevance 1.10 Pain Relevance 0

General Comments

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