INT199333

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Context Info
Confidence 0.65
First Reported 2006
Last Reported 2009
Negated 0
Speculated 1
Reported most in Body
Documents 8
Total Number 9
Disease Relevance 9.30
Pain Relevance 0.21

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Igfbp2) extracellular region (Igfbp2)
Igfbp2 (Mus musculus)
Pain Link Frequency Relevance Heat
anesthesia 9 91.88 High High
Inflammation 14 86.28 High High
metalloproteinase 1 81.36 Quite High
cytokine 7 5.00 Very Low Very Low Very Low
fibrosis 7 5.00 Very Low Very Low Very Low
Thoracotomy 6 5.00 Very Low Very Low Very Low
Inflammatory response 5 5.00 Very Low Very Low Very Low
ketamine 1 5.00 Very Low Very Low Very Low
Buprenorphine 1 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 641 99.84 Very High Very High Very High
Disease 11 99.48 Very High Very High Very High
Metastasis 16 98.76 Very High Very High Very High
Cancer 760 97.36 Very High Very High Very High
Apoptosis 120 97.04 Very High Very High Very High
Colon Cancer 328 95.92 Very High Very High Very High
Adenoma 288 95.12 Very High Very High Very High
Dislocations 18 93.00 High High
Fibrosis 17 86.68 High High
INFLAMMATION 19 86.28 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The higher IGFBP-2 levels in DMH-treated transgenic animals at the early and late stage of tumor development were not associated with any effect on tumor incidence.
Gene_expression (levels) of IGFBP-2 associated with targeted disruption and cancer
1) Confidence 0.65 Published 2006 Journal J Carcinog Section Body Doc Link PMC1660565 Disease Relevance 1.24 Pain Relevance 0
-catenin/TCF/LEF complex [52] it was not astonishing that we observed significantly higher IGFBP-2 serum levels in IGF-II transgenic mice and a positive correlation between serum IGF-II and IGFBP-2.
Gene_expression (levels) of IGFBP-2 associated with targeted disruption
2) Confidence 0.65 Published 2006 Journal J Carcinog Section Body Doc Link PMC1660565 Disease Relevance 1.42 Pain Relevance 0
-catenin-pathway is associated with increased IGFBP-2 serum levels in transgenic animals
Gene_expression (levels) of IGFBP-2 associated with targeted disruption
3) Confidence 0.65 Published 2006 Journal J Carcinog Section Body Doc Link PMC1660565 Disease Relevance 1.37 Pain Relevance 0
Serum IGF-II, IGF-I, and IGFBP-2 levels
Gene_expression (levels) of IGFBP-2
4) Confidence 0.65 Published 2006 Journal J Carcinog Section Body Doc Link PMC1660565 Disease Relevance 1.01 Pain Relevance 0
Since IGFBP2 is a target gene of the ?
Gene_expression (is) of IGFBP2
5) Confidence 0.65 Published 2006 Journal J Carcinog Section Body Doc Link PMC1660565 Disease Relevance 1.43 Pain Relevance 0
In addition to IGF-II, serum levels of IGF-I and IGF-binding protein-2 (IGFBP-2) were assessed in order to exclude that decreases in IGF-I and increases in IGFBP-2 antagonize the IGF-II effects in a compensatory manner [23].


Gene_expression (levels) of IGFBP-2
6) Confidence 0.58 Published 2006 Journal J Carcinog Section Body Doc Link PMC1660565 Disease Relevance 1.10 Pain Relevance 0
In addition to IGF-II, serum levels of IGF-I and IGF-binding protein-2 (IGFBP-2) were assessed in order to exclude that decreases in IGF-I and increases in IGFBP-2 antagonize the IGF-II effects in a compensatory manner [23].


Gene_expression (levels) of IGF-binding protein-2
7) Confidence 0.58 Published 2006 Journal J Carcinog Section Body Doc Link PMC1660565 Disease Relevance 1.10 Pain Relevance 0
Many genes involved in cell proliferation are also differentially expressed, including members of Igf1 signaling (up-regulation of Igf1, Igfbp2, Cyr61 and Pappa2 and down-regulation of Igfbp3), as well as Ctgf, Hbegf and Tnfrsf12a.
Gene_expression (expressed) of Igfbp2
8) Confidence 0.46 Published 2009 Journal Respir Res Section Body Doc Link PMC2770038 Disease Relevance 0.37 Pain Relevance 0.12
Serum concentrations of IGF-II, IGF-I and IGFBP-2 were determined by radioimmunoassays (RIAs), which were standardized in the hormone laboratory of the Children's Hospital, University of Tübingen as previously described [24].


Spec (determined) Gene_expression (concentrations) of IGFBP-2
9) Confidence 0.26 Published 2006 Journal J Carcinog Section Body Doc Link PMC1660565 Disease Relevance 0.25 Pain Relevance 0.09

General Comments

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