INT19934

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Context Info
Confidence 0.32
First Reported 1983
Last Reported 2010
Negated 1
Speculated 0
Reported most in Abstract
Documents 18
Total Number 18
Disease Relevance 6.18
Pain Relevance 5.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

isomerase activity (Ptgis) extracellular space (Ptgis) endoplasmic reticulum (Ptgis)
Anatomy Link Frequency
platelet 2
endothelial cells 1
endothelium 1
Ptgis (Mus musculus)
Pain Link Frequency Relevance Heat
tetrodotoxin 1 99.76 Very High Very High Very High
agonist 3 99.70 Very High Very High Very High
Migraine 14 99.68 Very High Very High Very High
aspirin 18 99.32 Very High Very High Very High
COX-2 inhibitor 4 98.98 Very High Very High Very High
cINOD 15 96.64 Very High Very High Very High
tolerance 100 95.64 Very High Very High Very High
Bioavailability 5 95.40 Very High Very High Very High
Paracetamol 12 94.92 High High
antagonist 6 91.88 High High
Disease Link Frequency Relevance Heat
Headache 10 99.68 Very High Very High Very High
Atherosclerosis 21 99.54 Very High Very High Very High
Pre-eclampsia 4 98.96 Very High Very High Very High
Vasculitis 2 98.88 Very High Very High Very High
Thrombosis 5 98.44 Very High Very High Very High
Asthma 5 97.84 Very High Very High Very High
INFLAMMATION 31 95.92 Very High Very High Very High
Adhesions 18 94.76 High High
Syndrome 4 94.00 High High
Cv Unclassified Under Development 5 89.52 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Evidence that prostacyclin deficiency is a specific feature in preeclampsia.
Negative_regulation (deficiency) of prostacyclin associated with pre-eclampsia
1) Confidence 0.32 Published 1984 Journal Am. J. Obstet. Gynecol. Section Title Doc Link 6367477 Disease Relevance 0.34 Pain Relevance 0.22
It is concluded that prostacyclin deficiency is not or not the only reason for the development of post-ischemic hypoperfusion and the associated disturbance of flow regulation.
Negative_regulation (deficiency) of prostacyclin
2) Confidence 0.32 Published 1983 Journal Stroke Section Abstract Doc Link 6362092 Disease Relevance 0.32 Pain Relevance 0.19
Moreover, oxidative inhibition of prostacyclin synthase [18] as well as mitochondrial ALDH activity [22] may present other key events in the development of nitrate tolerance.
Negative_regulation (inhibition) of prostacyclin synthase associated with tolerance
3) Confidence 0.13 Published 2006 Journal BMC Cardiovasc Disord Section Body Doc Link PMC1654181 Disease Relevance 0.16 Pain Relevance 0.36
Mice were given either pure PGI2 (PGI2 sodium salt), its stable agonist (iloprost) or inhibitor of prostacyclin (IP)-receptor (CAY-10441).
Negative_regulation (inhibitor) of prostacyclin associated with agonist
4) Confidence 0.10 Published 2009 Journal Coll Antropol Section Abstract Doc Link 20120521 Disease Relevance 0.16 Pain Relevance 0.95
CONCLUSION: Acetaminophen in typical oral doses results in reduced production of prostacyclin by endothelial cells in culture and in a reduction in prostacyclin, but not thromboxane, production in pregnant women.


Neg (not) Negative_regulation (reduction) of prostacyclin in endothelial cells
5) Confidence 0.06 Published 1993 Journal Am. J. Obstet. Gynecol. Section Body Doc Link 8475962 Disease Relevance 0 Pain Relevance 0
Tranylcypromine, which inhibits prostacyclin synthase, and tetrodotoxin, which blocks local reflexes, did not significantly affect the responses of the tissues to stretch.
Negative_regulation (inhibits) of prostacyclin synthase associated with tetrodotoxin
6) Confidence 0.05 Published 1993 Journal J. Appl. Physiol. Section Abstract Doc Link 8307867 Disease Relevance 0 Pain Relevance 0.19
Moreover, oxidative inhibition of prostacyclin synthase [84] as well as mitochondrial ALDH activity [85] may present other key events in the development of nitrate tolerance.
Negative_regulation (inhibition) of prostacyclin synthase associated with tolerance
7) Confidence 0.04 Published 2010 Journal Experimental Diabetes Research Section Body Doc Link PMC3014692 Disease Relevance 0.48 Pain Relevance 0.22
Inactivation of prostaglandin H synthase and prostacyclin synthase by phenylbutazone.
Negative_regulation (Inactivation) of prostacyclin synthase
8) Confidence 0.04 Published 1985 Journal Mol. Pharmacol. Section Title Doc Link 3917545 Disease Relevance 0.10 Pain Relevance 0.10
As PB undergoes peroxide-dependent co-oxygenation catalyzed by PHS, we propose that it is an oxygenated derivative of PB, rather than the parent compound, which is responsible for the inactivation of PHS and prostacyclin synthase.
Negative_regulation (inactivation) of prostacyclin synthase
9) Confidence 0.04 Published 1985 Journal Mol. Pharmacol. Section Abstract Doc Link 3917545 Disease Relevance 0 Pain Relevance 0
Even partial suppression of prostacyclin (without coincident inhibition of platelet COX-1-dependent thromboxane formation) by COX-2 inhibitors may be undesirable in acute vascular occlusive syndromes.
Negative_regulation (suppression) of prostacyclin in platelet associated with syndrome and cox-2 inhibitor
10) Confidence 0.04 Published 2000 Journal Ann. Med. Section Abstract Doc Link 11209977 Disease Relevance 0.70 Pain Relevance 0.38
This is consistent with the failure of biochemically defined, selective doses of a COX-2 inhibitor to accelerate atherogenesis in the mouse, despite suppressing prostacyclin biosynthesis by roughly 60%.
Negative_regulation (suppressing) of prostacyclin associated with atherosclerosis and cox-2 inhibitor
11) Confidence 0.04 Published 2000 Journal Ann. Med. Section Abstract Doc Link 11209977 Disease Relevance 0.65 Pain Relevance 0.28
Modulation of hemostasis includes the release of plasminogen activator, tissue factor inhibitor, von Willebrand factor, NO, prostacyclin, TXA2, plasminogen-activator inhibitor-1 (PAI-1), and fibrinogen.
Negative_regulation (inhibitor) of prostacyclin
12) Confidence 0.02 Published 2005 Journal Vascular Health and Risk Management Section Body Doc Link PMC1993938 Disease Relevance 0.89 Pain Relevance 0.12
Inhibition of prostacyclin biosynthesis by aspirin might be expected to promote asthmatic attacks in aspirin-intolerant patients.
Negative_regulation (Inhibition) of prostacyclin associated with asthma and aspirin
13) Confidence 0.02 Published 1987 Journal Allerg Immunol (Paris) Section Abstract Doc Link 3331264 Disease Relevance 0.24 Pain Relevance 0.24
The prostacyclin metabolite 6-keto-PGF 1 alpha was significantly decreased in the migraine group.
Negative_regulation (decreased) of prostacyclin associated with migraine
14) Confidence 0.01 Published 1988 Journal Acta Neurol. Scand. Section Abstract Doc Link 2851913 Disease Relevance 0.67 Pain Relevance 0.63
These data do not confirm a general platelet malfunction in migraine patients, but suggest a decreased functional capacity of platelet beta-adrenoceptors and an altered metabolism of prostacyclin and LDL-cholesterol.
Negative_regulation (metabolism) of prostacyclin in platelet associated with migraine
15) Confidence 0.01 Published 1988 Journal Acta Neurol. Scand. Section Abstract Doc Link 2851913 Disease Relevance 0.61 Pain Relevance 0.58
Animal studies show that inhibition of prostacyclin activity does not lead to spontaneous thrombosis but may increase response to thrombotic stimuli.
Negative_regulation (inhibition) of prostacyclin associated with thrombosis
16) Confidence 0.01 Published 2002 Journal Am. J. Cardiol. Section Abstract Doc Link 11909558 Disease Relevance 0.51 Pain Relevance 0.24
The clinical sequelae of inhibiting prostacyclin activity in the absence of concomitant inhibition of TXA(2) are not currently clear.
Negative_regulation (inhibiting) of prostacyclin
17) Confidence 0.01 Published 2002 Journal Am. J. Cardiol. Section Abstract Doc Link 11909558 Disease Relevance 0.36 Pain Relevance 0.18
Prostacyclin, thromboxane B2, and an inhibitor of collagen- and epinephrine-induced platelet aggregation (B13.177) did not affect SS RBC adherence to endothelium.
Negative_regulation (inhibitor) of Prostacyclin in endothelium
18) Confidence 0.00 Published 1990 Journal Am. J. Hematol. Section Abstract Doc Link 2109530 Disease Relevance 0 Pain Relevance 0.17

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