INT199342

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Context Info
Confidence 0.60
First Reported 2006
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 3.30
Pain Relevance 0.50

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Igfbp2) extracellular region (Igfbp2)
Igfbp2 (Mus musculus)
Pain Link Frequency Relevance Heat
chemokine 12 98.84 Very High Very High Very High
Inflammation 28 84.24 Quite High
metalloproteinase 2 81.36 Quite High
Bioavailability 2 67.84 Quite High
adenocard 2 66.92 Quite High
cytokine 18 65.44 Quite High
fibrosis 14 60.76 Quite High
alcohol 22 5.00 Very Low Very Low Very Low
Thoracotomy 12 5.00 Very Low Very Low Very Low
Inflammatory response 10 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 198 96.96 Very High Very High Very High
Targeted Disruption 162 93.28 High High
Emphysema 2 87.28 High High
Adhesions 10 85.88 High High
Fibrosis 34 84.64 Quite High
INFLAMMATION 38 84.24 Quite High
Hyperplasia 8 74.16 Quite High
Asthma 4 73.48 Quite High
Natriuresis 2 68.12 Quite High
Disease 8 67.08 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Insulin-like growth factor–binding protein 2 was down regulated (Table 3), which is a reflection of the down regulation of the pathways in cancer (Table 3; Fig. 3).


Regulation (regulated) of Insulin-like growth factor-binding protein 2 associated with cancer
1) Confidence 0.60 Published 2010 Journal Genes Nutr Section Body Doc Link PMC2988994 Disease Relevance 0.64 Pain Relevance 0.26
DMH-treatment also had no influence on serum IGFBP-2 levels in both genotypes and at both time points measured (Fig. 1B).
Neg (no) Regulation (influence) of IGFBP-2
2) Confidence 0.60 Published 2006 Journal J Carcinog Section Body Doc Link PMC1660565 Disease Relevance 0.82 Pain Relevance 0
That the biological effects of IGF-II are strictly dependent on IGFBP-2 can be further derived from the increase of both IGF-II and IGFBP-2 in wild-type mice with age.
Regulation (dependent) of IGFBP-2
3) Confidence 0.44 Published 2006 Journal J Carcinog Section Body Doc Link PMC1660565 Disease Relevance 0.91 Pain Relevance 0
The actions of Igf1 depend largely on its binding to extracellular proteins such as Igfbp2 and Igfbp3 [29-31].
Regulation (depend) of Igfbp2
4) Confidence 0.34 Published 2009 Journal Respir Res Section Body Doc Link PMC2770038 Disease Relevance 0.56 Pain Relevance 0.13
Many genes involved in cell proliferation are also differentially expressed, including members of Igf1 signaling (up-regulation of Igf1, Igfbp2, Cyr61 and Pappa2 and down-regulation of Igfbp3), as well as Ctgf, Hbegf and Tnfrsf12a.
Regulation (regulation) of Igfbp2
5) Confidence 0.20 Published 2009 Journal Respir Res Section Body Doc Link PMC2770038 Disease Relevance 0.37 Pain Relevance 0.11

General Comments

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