INT199343

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Context Info
Confidence 0.67
First Reported 2006
Last Reported 2009
Negated 1
Speculated 0
Reported most in Body
Documents 8
Total Number 8
Disease Relevance 7.85
Pain Relevance 0.28

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Igfbp2) extracellular region (Igfbp2)
Anatomy Link Frequency
colon 1
lung 1
Igfbp2 (Mus musculus)
Pain Link Frequency Relevance Heat
Spinal cord 40 82.48 Quite High
Central nervous system 10 74.56 Quite High
Bioavailability 1 72.56 Quite High
cytokine 7 61.20 Quite High
Inflammation 18 60.64 Quite High
fibrosis 7 56.52 Quite High
chemokine 1 42.32 Quite Low
Inflammatory response 6 8.16 Low Low
anesthesia 10 5.00 Very Low Very Low Very Low
Thoracotomy 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 484 99.84 Very High Very High Very High
Colon Cancer 246 99.84 Very High Very High Very High
Motor Neuron Diseases 36 99.56 Very High Very High Very High
Disease 55 98.68 Very High Very High Very High
Cancer 570 95.52 Very High Very High Very High
Adenoma 216 95.52 Very High Very High Very High
Metastasis 12 94.20 High High
Emphysema 1 92.00 High High
Aberrant Crypt Foci 252 87.20 High High
Apoptosis 90 86.32 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
At 44 weeks serum IGFBP-2 levels were significantly increased in transgenic mice treated with DMH versus DMH-treated wild-type mice but no longer different between both genotypes when untreated (Fig. 1B).


Positive_regulation (increased) of IGFBP-2 associated with targeted disruption
1) Confidence 0.67 Published 2006 Journal J Carcinog Section Body Doc Link PMC1660565 Disease Relevance 1.03 Pain Relevance 0
Given that the increase of IGF-II in transgenic animals was much more pronounced than the increase of IGFBP-2 it could be concluded that IGFBP-2 is not able to block completely the effects of the transgene.
Positive_regulation (increase) of IGFBP-2 associated with targeted disruption
2) Confidence 0.67 Published 2006 Journal J Carcinog Section Body Doc Link PMC1660565 Disease Relevance 1.36 Pain Relevance 0
In addition to IGF-II, serum levels of IGF-I and IGF-binding protein-2 (IGFBP-2) were assessed in order to exclude that decreases in IGF-I and increases in IGFBP-2 antagonize the IGF-II effects in a compensatory manner [23].


Positive_regulation (increases) of IGFBP-2
3) Confidence 0.67 Published 2006 Journal J Carcinog Section Body Doc Link PMC1660565 Disease Relevance 1.03 Pain Relevance 0
That the biological effects of IGF-II are strictly dependent on IGFBP-2 can be further derived from the increase of both IGF-II and IGFBP-2 in wild-type mice with age.
Positive_regulation (increase) of IGFBP-2
4) Confidence 0.67 Published 2006 Journal J Carcinog Section Body Doc Link PMC1660565 Disease Relevance 0.86 Pain Relevance 0
In accordance with this, in our studies one animal showed tremendously increased IGFBP-2 levels at a later stage that correlated well with its very poor status because of development of several large adenomas spreading over the middle and distal colon.


Positive_regulation (increased) of IGFBP-2 in colon associated with adenoma
5) Confidence 0.67 Published 2006 Journal J Carcinog Section Body Doc Link PMC1660565 Disease Relevance 0.81 Pain Relevance 0
On the other hand in the case of a manifested colorectal cancer, serum IGFBP-2 levels are significantly elevated and correlate with the stage of disease [51].
Positive_regulation (elevated) of IGFBP-2 associated with colon cancer and disease
6) Confidence 0.48 Published 2006 Journal J Carcinog Section Body Doc Link PMC1660565 Disease Relevance 1.41 Pain Relevance 0
While Igf1 and Igfbp2 are up-regulated during lung regeneration, Igfbp3 is down-regulated.
Positive_regulation (up-regulated) of Igfbp2 in lung
7) Confidence 0.35 Published 2009 Journal Respir Res Section Body Doc Link PMC2770038 Disease Relevance 0.54 Pain Relevance 0.13
However, Pirttila et al. [48] showed that insulin-like growth factor (IGF)-1, IGF binding protein-2, or nitric oxide were not elevated in CSF of ALS patients, suggesting that there is not a major disruption in the BCSFB.
Neg (not) Positive_regulation (elevated) of IGF binding protein-2 associated with motor neuron diseases
8) Confidence 0.27 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2075163 Disease Relevance 0.80 Pain Relevance 0.15

General Comments

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