INT199345

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Context Info
Confidence 0.50
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 11
Total Number 13
Disease Relevance 8.44
Pain Relevance 0.89

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Lyve1) transport (Lyve1) cell adhesion (Lyve1)
plasma membrane (Lyve1)
Anatomy Link Frequency
endothelial cells 4
blood 2
vessels 1
lymphatic vessels 1
Lyve1 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 19 96.08 Very High Very High Very High
Inflammation 90 95.68 Very High Very High Very High
cINOD 30 93.76 High High
imagery 220 68.44 Quite High
chemokine 5 33.04 Quite Low
anesthesia 15 16.96 Low Low
isoflurane 17 15.12 Low Low
Arthritis 29 5.00 Very Low Very Low Very Low
rheumatoid arthritis 8 5.00 Very Low Very Low Very Low
antagonist 7 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Bladder Cancer 129 100.00 Very High Very High Very High
Cancer 737 99.76 Very High Very High Very High
Overactive Bladder 8 99.36 Very High Very High Very High
Metastasis 240 97.04 Very High Very High Very High
INFLAMMATION 85 95.68 Very High Very High Very High
Apoptosis 42 93.92 High High
Targeted Disruption 189 88.32 High High
Carcinoma 43 86.40 High High
Congenital Anomalies 36 86.00 High High
Lymphedema 49 85.20 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Figure 4A–D is a representative photomicrograph of sub-urothelial lymphatic vessels illustrating the finding that some of the lymphatic endothelial cells were positive for both LYVE-1 and Ki-67.
Gene_expression (positive) of LYVE-1 in lymphatic vessels
1) Confidence 0.50 Published 2007 Journal BMC Cancer Section Body Doc Link PMC2241841 Disease Relevance 0.34 Pain Relevance 0
Expression of LYVE-1 did not differ significantly among experimental cohorts.


Gene_expression (Expression) of LYVE-1
2) Confidence 0.49 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2791214 Disease Relevance 0.64 Pain Relevance 0.65
Adjacent serial sections were then stained with anti-LYVE-1 or anti-CD31 antibodies.
Gene_expression (stained) of anti-LYVE-1
3) Confidence 0.48 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2246237 Disease Relevance 0.09 Pain Relevance 0.03
Quantitative detection of LYVE-1, a marker for lymphangiogenesis, was used to reveal effects of IGF-II on metastasis.
Gene_expression (detection) of LYVE-1 associated with metastasis
4) Confidence 0.45 Published 2006 Journal J Carcinog Section Body Doc Link PMC1660565 Disease Relevance 1.01 Pain Relevance 0
LYVE-1 staining was correlated with ?
Gene_expression (staining) of LYVE-1
5) Confidence 0.44 Published 2007 Journal BMC Cancer Section Body Doc Link PMC2241841 Disease Relevance 0.19 Pain Relevance 0.04
Our present findings indicate that in addition to LYVE-1-positive lymphatic endothelial cells, during bladder cancer development, LYVE-1 positive macrophages were found in the bladder detrusor muscle isolated from SV40-lacZ mice.
Gene_expression (found) of LYVE-1 in endothelial cells associated with bladder cancer and overactive bladder
6) Confidence 0.44 Published 2007 Journal BMC Cancer Section Body Doc Link PMC2241841 Disease Relevance 0.95 Pain Relevance 0.09
Our present findings indicate that in addition to LYVE-1-positive lymphatic endothelial cells, during bladder cancer development, LYVE-1 positive macrophages were found in the bladder detrusor muscle isolated from SV40-lacZ mice.
Gene_expression (macrophages) of LYVE-1 in endothelial cells associated with bladder cancer and overactive bladder
7) Confidence 0.44 Published 2007 Journal BMC Cancer Section Body Doc Link PMC2241841 Disease Relevance 0.88 Pain Relevance 0.08
Numbers of blood microvessels with CD34+/Lyve-1- and lymphatic microvessels with CD34-/Lyve-1+ were counted on the merged images (Figure 4C, F, I, L).
Gene_expression (counted) of Lyve-1 in blood
8) Confidence 0.39 Published 2010 Journal BMC Med Section Body Doc Link PMC2989928 Disease Relevance 0.88 Pain Relevance 0
The corresponding three images (CD34, Lyve-1 and DAPI) were merged into a single image and the number of CD34+/Lyve-1- and the number of CD34-/Lyve-1+ vessels were counted.


Gene_expression (vessels) of Lyve-1 in vessels
9) Confidence 0.39 Published 2010 Journal BMC Med Section Body Doc Link PMC2989928 Disease Relevance 0.61 Pain Relevance 0
Numbers of blood microvessels with CD34+/Lyve-1- and lymphatic microvessels with CD34-/Lyve-1+ were counted on the merged images (Figure 4C, F, I, L).
Gene_expression (counted) of Lyve-1 in blood
10) Confidence 0.39 Published 2010 Journal BMC Med Section Body Doc Link PMC2989928 Disease Relevance 1.00 Pain Relevance 0
As evidenced by Figure 3B, many various-sized tumor cell nests circumscribed with the LYVE-1-positive brown signal were observed in EBC1-V1-derived tumor tissue (Figure 3B, EBC1-V1/LYVE-1, arrows).
Gene_expression (circumscribed) of LYVE-1 associated with cancer
11) Confidence 0.15 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2987985 Disease Relevance 1.09 Pain Relevance 0
Immunohistochemical studies, especially those focusing on CD31 (an endothelial marker), CD34 (expressed by blood vascular endothelial cells), D2-40 and LYVE-1 (lymphatic endothalial cells), markers of vascular proliferation such as the MIB1 proliferative index and VEGF expression within the lesions, would appear to be more useful for subdividing, or on the contrary uniting, these pathological entities.
Gene_expression (expressed) of LYVE-1 in endothelial cells
12) Confidence 0.04 Published 2010 Journal Orphanet J Rare Dis Section Body Doc Link PMC2830950 Disease Relevance 0.37 Pain Relevance 0
Immunohistochemical studies, especially those focusing on CD31 (an endothelial marker), CD34 (expressed by blood vascular endothelial cells), D2-40 and LYVE-1 (lymphatic endothalial cells), markers of vascular proliferation such as the MIB1 proliferative index and VEGF expression within the lesions, would appear to be more useful for subdividing, or on the contrary uniting, these pathological entities.
Gene_expression (expression) of LYVE-1 in endothelial cells
13) Confidence 0.04 Published 2010 Journal Orphanet J Rare Dis Section Body Doc Link PMC2830950 Disease Relevance 0.39 Pain Relevance 0

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