INT199349

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Context Info
Confidence 0.50
First Reported 2006
Last Reported 2010
Negated 2
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 4.56
Pain Relevance 0.15

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Igf2) extracellular region (Igf2) carbohydrate metabolic process (Igf2)
Anatomy Link Frequency
colon 4
embryos 2
Igf2 (Mus musculus)
Pain Link Frequency Relevance Heat
tolerance 1 71.88 Quite High
pain pelvic 2 61.68 Quite High
Pain 1 56.44 Quite High
anesthesia 3 5.00 Very Low Very Low Very Low
Hippocampus 2 5.00 Very Low Very Low Very Low
alcohol 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Colon Cancer 123 99.84 Very High Very High Very High
Targeted Disruption 240 99.36 Very High Very High Very High
Gestational Diabetes 12 98.88 Very High Very High Very High
Adenoma 108 96.52 Very High Very High Very High
Birth Weight 10 96.48 Very High Very High Very High
Malignant Neoplastic Disease 12 96.40 Very High Very High Very High
Colorectal Cancer 18 94.80 High High
Metastasis 6 86.28 High High
Cancer 286 84.48 Quite High
Uterine Fibroids 94 83.72 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Two studies in mice have reported that exposure of fetuses to induced maternal diabetes and of embryos before implantation to in vitro insulin affected expression of two imprinted neighboring genes, H19 and IGF2, by altering their methylation status and resulted in changes in fetal development and birth weight (Shao et al. 2007, 2008).
Regulation (affected) of Gene_expression (expression) of IGF2 in embryos associated with birth weight and gestational diabetes
1) Confidence 0.50 Published 2010 Journal Environ Health Perspect Section Body Doc Link PMC2854766 Disease Relevance 1.52 Pain Relevance 0.15
Lymphangiogenesis in colon tumors is not affected by IGF-II overexpression
Neg (not) Regulation (affected) of Gene_expression (overexpression) of IGF-II in colon associated with colon cancer
2) Confidence 0.45 Published 2006 Journal J Carcinog Section Body Doc Link PMC1660565 Disease Relevance 0.89 Pain Relevance 0
DMH-treatment does not affect IGF-II expression
Neg (not) Regulation (affect) of Gene_expression (expression) of IGF-II
3) Confidence 0.45 Published 2006 Journal J Carcinog Section Body Doc Link PMC1660565 Disease Relevance 1.06 Pain Relevance 0
Female NMRI mice, overexpressing human IGF-II under the control of the rat phosphoenolpyruvate carboxykinase (PEPCK) promoter in several tissues including colon [24] and their non-transgenic female NMRI littermates were used in this study.
Regulation (under) of Gene_expression (overexpressing) of IGF-II in colon associated with targeted disruption
4) Confidence 0.27 Published 2006 Journal J Carcinog Section Body Doc Link PMC1660565 Disease Relevance 1.09 Pain Relevance 0

General Comments

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