INT199354

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Context Info
Confidence 0.72
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 13
Total Number 14
Disease Relevance 5.57
Pain Relevance 0.26

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lyase activity (Pck1) nucleus (Pck1) kinase activity (Pck1)
lipid metabolic process (Pck1) cytoplasm (Pck1)
Anatomy Link Frequency
liver 2
fat 1
adipose tissue 1
Pck1 (Mus musculus)
Pain Link Frequency Relevance Heat
tolerance 161 94.44 High High
agonist 39 65.92 Quite High
Inflammatory response 3 55.52 Quite High
Inflammation 34 50.00 Quite Low
cytokine 17 38.96 Quite Low
Eae 6 25.24 Quite Low
metalloproteinase 32 5.00 Very Low Very Low Very Low
antagonist 28 5.00 Very Low Very Low Very Low
anesthesia 20 5.00 Very Low Very Low Very Low
Kinase C 10 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 232 100.00 Very High Very High Very High
Insulin Resistance 205 99.44 Very High Very High Very High
Diabetes Mellitus 182 98.98 Very High Very High Very High
Obesity 352 98.00 Very High Very High Very High
Hyperglycemia 23 97.20 Very High Very High Very High
Hepatocellular Cancer 4 96.40 Very High Very High Very High
Impaired Glucose Tolerance 143 94.44 High High
Metastasis 2 89.28 High High
Cancer 97 82.08 Quite High
Body Weight 72 80.16 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A twofold overexpression of PEPCK-C results in insulin resistance (4), whereas a sevenfold overexpression results in hyperglycemia (5).
Gene_expression (overexpression) of PEPCK associated with hyperglycemia and insulin resistance
1) Confidence 0.72 Published 2008 Journal Diabetes Section Body Doc Link PMC2494684 Disease Relevance 0.87 Pain Relevance 0
Data presented in this manuscript, together with our previous study in streptozotocin-induced diabetic animals (12), demonstrate that a 50% reduction of PEPCK expression results in reduced HGO and glycemia.
Gene_expression (expression) of PEPCK associated with diabetes mellitus
2) Confidence 0.72 Published 2008 Journal Diabetes Section Body Doc Link PMC2494684 Disease Relevance 0.30 Pain Relevance 0
Because PEPCK-C is not only required for gluconeogenesis and glyceroneogenesis but also for cataplerosis (i.e., the removal of citric acid cycle anions), the failure of this process would result in an impairment in the TCA cycle and mitochondrial function in the liver, leading to decreased ?
Gene_expression (Because) of PEPCK in liver
3) Confidence 0.62 Published 2008 Journal Diabetes Section Body Doc Link PMC2494684 Disease Relevance 0.24 Pain Relevance 0.03
reduces hepatic glucose output along with downregulation of PEPCK and G6Pase expression (33).
Gene_expression (expression) of PEPCK
4) Confidence 0.60 Published 2008 Journal Diabetes Section Body Doc Link PMC2494675 Disease Relevance 0.45 Pain Relevance 0.08
The regulation of gluconeogenesis predominantly depends on the expression level of gluconeogenic genes such as PEPCK and G6Pase (31,32).
Gene_expression (expression) of PEPCK
5) Confidence 0.60 Published 2008 Journal Diabetes Section Body Doc Link PMC2494675 Disease Relevance 0.57 Pain Relevance 0
Treatment with Ad-shPck1 achieved a 42 and 25% reduction in Pck1 gene expression in fed and fasted livers, respectively (Fig. 1A).
Gene_expression (expression) of Pck1 in livers
6) Confidence 0.56 Published 2008 Journal Diabetes Section Body Doc Link PMC2494684 Disease Relevance 0.13 Pain Relevance 0
myel-mice exhibited a 50% reduction in the hepatic expression of a key enzyme of gluconeogenesis, glucose-6-phosphatase (G6Pase), while expression of phosphoenolpyruvate carboxykinase (Pck1) remained unchanged (Figure 2F).
Gene_expression (expression) of Pck1
7) Confidence 0.50 Published 2010 Journal PLoS Genetics Section Body Doc Link PMC2865520 Disease Relevance 0.81 Pain Relevance 0.08
Overexpression of SOD1 significantly reduced the expression levels of PEPCK, the rate-limiting enzyme of gluconeogenesis.
Gene_expression (expression) of PEPCK
8) Confidence 0.46 Published 2008 Journal Diabetes Section Body Doc Link PMC2494675 Disease Relevance 0.21 Pain Relevance 0.03
target genes Lpl, PEPCK, CD36, and adiponectin was markedly decreased in adipose tissue from PPAR?
Gene_expression (genes) of PEPCK in adipose tissue associated with obesity
9) Confidence 0.37 Published 2008 Journal PLoS Genetics Section Body Doc Link PMC2432036 Disease Relevance 0.33 Pain Relevance 0.03
target genes (Lpl, PEPCK, CD36 and adiponectin) in gonadal fat isolated from these mice revealed no significant differences in the expression level between vehicle and DPN-treated rodents indicating ligand independency (Figure 4C).
Gene_expression (expression) of PEPCK in fat
10) Confidence 0.37 Published 2008 Journal PLoS Genetics Section Body Doc Link PMC2432036 Disease Relevance 0.06 Pain Relevance 0
The expression level of PEPCK and Lpl was significantly increased in both wt and ?
Gene_expression (expression) of PEPCK
11) Confidence 0.33 Published 2008 Journal PLoS Genetics Section Body Doc Link PMC2432036 Disease Relevance 0.16 Pain Relevance 0
Identification of PEPCK-IGF-II transgenic animals and carcinogen treatment
Gene_expression (animals) of PEPCK associated with targeted disruption
12) Confidence 0.30 Published 2006 Journal J Carcinog Section Body Doc Link PMC1660565 Disease Relevance 1.04 Pain Relevance 0
Whereas on the other hand, it diminished phospho protein kinase B (pAKT) and phospho-glycogen synthase kinase (pGSK) levels in both cell lines and upregulated gluconeogenesis in H4-II-E-cells by attenuating the effect of insulin on the expression on PEPCK [73].
Gene_expression (expression) of PEPCK
13) Confidence 0.17 Published 2010 Journal International Journal of Peptides Section Body Doc Link PMC2911604 Disease Relevance 0.16 Pain Relevance 0
It acts predominantly by suppressing the expression of the genes for the key gluconeogenic enzymes PEPCK and G6Pase [116].
Gene_expression (expression) of PEPCK
14) Confidence 0.15 Published 2010 Journal International Journal of Peptides Section Body Doc Link PMC2911604 Disease Relevance 0.25 Pain Relevance 0

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