INT199391

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Context Info
Confidence 0.31
First Reported 2006
Last Reported 2006
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 1.28
Pain Relevance 0.87

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Pklr) signal transduction (Prokr1) plasma membrane (Prokr1)
carbohydrate metabolic process (Pklr) kinase activity (Pklr) signal transducer activity (Prokr1)
Pklr (Mus musculus)
Prokr1 (Mus musculus)
Pain Link Frequency Relevance Heat
Potency 1 99.44 Very High Very High Very High
IPN 6 95.40 Very High Very High Very High
cytokine 1 93.60 High High
Inflammation 13 89.64 High High
Pain 12 84.48 Quite High
qutenza 31 72.72 Quite High
dorsal root ganglion 26 66.52 Quite High
Hyperalgesia 5 58.60 Quite High
withdrawal 8 47.68 Quite Low
Inflammatory response 8 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Nociception 31 96.48 Very High Very High Very High
Inflammatory Pain 6 95.40 Very High Very High Very High
INFLAMMATION 19 89.64 High High
Pain 12 84.48 Quite High
Ganglion Cysts 26 66.52 Quite High
Hyperalgesia 6 58.60 Quite High
Pressure And Volume Under Development 2 5.00 Very Low Very Low Very Low
Body Weight 2 5.00 Very Low Very Low Very Low
Neurogenic Inflammation 2 5.00 Very Low Very Low Very Low
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super / Visceral Pain

2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Thus, even though PK1 activates PKR1 with similar potency in vitro as PK2 [3], PK2 might be the dominant ligand involved in nociception, especially in inflammatory pain.
PK1 Positive_regulation (activates) of PKR1 associated with nociception, ipn and potency
1) Confidence 0.31 Published 2006 Journal Mol Pain Section Body Doc Link PMC1660571 Disease Relevance 1.28 Pain Relevance 0.87

General Comments

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