INT199406

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Context Info
Confidence 0.40
First Reported 2005
Last Reported 2005
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0
Pain Relevance 0.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endoplasmic reticulum (CYP3A4, PPIB) unfolded protein binding (PPIB) isomerase activity (PPIB)
small molecule metabolic process (CYP3A4) enzyme binding (CYP3A4) lipid metabolic process (CYP3A4)
CYP3A4 (Homo sapiens)
PPIB (Homo sapiens)
Pain Link Frequency Relevance Heat
Potency 2 79.60 Quite High
Versed 7 5.00 Very Low Very Low Very Low
rapifen 4 5.00 Very Low Very Low Very Low
carbamazepine 3 5.00 Very Low Very Low Very Low
cytokine 2 5.00 Very Low Very Low Very Low
lidocaine 2 5.00 Very Low Very Low Very Low
Paracetamol 2 5.00 Very Low Very Low Very Low
Inflammation 1 5.00 Very Low Very Low Very Low
Bioavailability 1 5.00 Very Low Very Low Very Low
antagonist 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Toxicity 16 5.00 Very Low Very Low Very Low
Arrhythmia Under Development 3 5.00 Very Low Very Low Very Low
Hypertension 2 5.00 Very Low Very Low Very Low
Rhabdomyolysis 2 5.00 Very Low Very Low Very Low
Cv General 2 Under Development 2 5.00 Very Low Very Low Very Low
Death 1 5.00 Very Low Very Low Very Low
Breast Cancer 1 5.00 Very Low Very Low Very Low
Aging 1 5.00 Very Low Very Low Very Low
Injury 1 5.00 Very Low Very Low Very Low
Hepatotoxicity 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Irreversible inhibition of CYP3A4 due to enzyme inactivation or complexation occurs when some therapeutic drugs are converted by CYPs to reactive metabolites capable of covalently binding to CYP3A4 protein or heme moiety.
CYP3A4 Binding (binding) of CYPs
1) Confidence 0.40 Published 2005 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC1661603 Disease Relevance 0 Pain Relevance 0.04

General Comments

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