INT19941

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Context Info
Confidence 0.42
First Reported 1981
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 13
Total Number 13
Disease Relevance 10.35
Pain Relevance 5.97

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Pf4) extracellular region (Pf4) protein complex assembly (Pf4)
molecular_function (Pf4) protein complex (Pf4)
Anatomy Link Frequency
plasma 6
platelet 3
Coronary artery 1
blood 1
endothelial cell 1
Pf4 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
depression 18 99.98 Very High Very High Very High
Migraine 18 99.80 Very High Very High Very High
Cluster headache 5 99.74 Very High Very High Very High
aspirin 34 98.96 Very High Very High Very High
Angina 20 98.70 Very High Very High Very High
headache 5 96.12 Very High Very High Very High
ischemia 15 91.96 High High
Restless leg syndrome 2 87.72 High High
Pain 2 87.04 High High
tolerance 8 85.88 High High
Disease Link Frequency Relevance Heat
Depression 18 99.98 Very High Very High Very High
Migraine With Aura 7 99.80 Very High Very High Very High
Cluster Headache 5 99.74 Very High Very High Very High
Acute Coronary Syndrome 51 99.68 Very High Very High Very High
Cv General 3 Under Development 32 98.70 Very High Very High Very High
Adhesions 9 97.84 Very High Very High Very High
Thrombocytosis 6 96.68 Very High Very High Very High
Erythermalgia 6 96.56 Very High Very High Very High
Myocardial Infarction 30 96.28 Very High Very High Very High
Headache 13 96.12 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Administration of aspirin to the patients affected by common and classic migraine caused a decrease in plasma beta-TG and PF4 concentration.
Negative_regulation (decrease) of PF4 in plasma associated with aspirin, migraine with aura and migraine
1) Confidence 0.42 Published 1984 Journal Stroke Section Abstract Doc Link 6230778 Disease Relevance 0.79 Pain Relevance 1.08
Administration of aspirin (ASA) was more effective than flunarizine in inducing a decrease in beta-TG and PF4 plasma levels in migraineurs.
Negative_regulation (decrease) of PF4 in plasma associated with aspirin
2) Confidence 0.41 Published 1985 Journal Cephalalgia Section Abstract Doc Link 3160472 Disease Relevance 0.89 Pain Relevance 0.89
Coronary artery bypass grafting in a subgroup of patients did not affect the mean plasma PF4 concentration during 1 year of follow-up after bypass surgery, but medical therapy for angina with increasing doses of propranolol and nitrates significantly reduced PF4 concentration in another subgroup of patients who were not considered to be candidates for surgical therapy.
Negative_regulation (reduced) of PF4 in Coronary artery associated with angina
3) Confidence 0.39 Published 1981 Journal Circulation Section Abstract Doc Link 6973419 Disease Relevance 0.91 Pain Relevance 0.36
However, during the attacks of cluster headache beta-TG and PF4 plasma levels decreased by 42% and 50%, respectively, in comparison with plasma concentrations measured outside of attack.
Negative_regulation (decreased) of PF4 in plasma associated with cluster headache
4) Confidence 0.37 Published 1986 Journal Cephalalgia Section Abstract Doc Link 2945644 Disease Relevance 0.66 Pain Relevance 0.66
The in vitro platelet reactivity to ADP was determined at rest and the plasma levels of beta-thromboglobulin (BTG) and platelet factor 4 (PF4) were measured before and immediately after exercise.
Negative_regulation (measured) of platelet factor 4 in plasma
5) Confidence 0.36 Published 1987 Journal Eur. Heart J. Section Abstract Doc Link 2949974 Disease Relevance 0.25 Pain Relevance 0.38
The in vitro platelet reactivity to ADP was determined at rest and the plasma levels of beta-thromboglobulin (BTG) and platelet factor 4 (PF4) were measured before and immediately after exercise.
Negative_regulation (measured) of PF4 in plasma
6) Confidence 0.36 Published 1987 Journal Eur. Heart J. Section Abstract Doc Link 2949974 Disease Relevance 0.24 Pain Relevance 0.38
Likewise, plasma PF4 levels decreased significantly during beraprost sodium administration (p < 0.05).
Negative_regulation (decreased) of PF4 in plasma
7) Confidence 0.26 Published 1995 Journal Cardiovasc Drugs Ther Section Abstract Doc Link 8547211 Disease Relevance 0.49 Pain Relevance 0.34
Aspirin treatment of erythromelalgia in thrombocythemia patients resulted in the disappearance of the erythromelalgic, thrombotic signs and symptoms, correction of the shortened platelet survival times, and a significant reduction of the increased levels of beta-TG, PF4, TM and urinary TxB2 excretion to normal.
Negative_regulation (reduction) of PF4 in platelet associated with aspirin, thrombocytosis and erythermalgia
8) Confidence 0.12 Published 2003 Journal Pathol. Biol. Section Abstract Doc Link 12781799 Disease Relevance 1.42 Pain Relevance 0.30
UFH and LMWH can be inactivated by platelet factor 4 (PF4) (Eitzman et al 1994) and the subsequent UFH(LMWH)-PF4 complex may act as a source of immunoglobin G mediated HIT (HIT Type II) (Chong 2003; Lehman and Chew 2006).
Negative_regulation (inactivated) of PF4 in platelet associated with heparin-induced thrombocytopenia
9) Confidence 0.06 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2515410 Disease Relevance 0.30 Pain Relevance 0.04
Levels of fibrinopeptide A, beta-thromboglobulin, platelet factor 4, thromboxane B2 and the platelet aggregates ratio in blood were similar between the 2 groups before, during and after PGI2 infusion.
Negative_regulation (Levels) of platelet factor 4 in blood
10) Confidence 0.04 Published 1990 Journal Am. J. Cardiol. Section Abstract Doc Link 2109927 Disease Relevance 0.49 Pain Relevance 0.40
Ticlopidine and aspirin/dipyridamole, but not xanthinol nicotinate, improved platelet aggregation, reduced beta-thromboglobulin, platelet factor IV and fibrinopeptide A concentrations, and increased antithrombin III concentrations and red blood cell filterability.
Negative_regulation (reduced) of platelet factor IV in red blood cell associated with aspirin
11) Confidence 0.02 Published 1990 Journal J. Int. Med. Res. Section Abstract Doc Link 2147914 Disease Relevance 0.16 Pain Relevance 0.30
Surprisingly, patients with ACS and depression exhibited the highest levels of platelet factor 4, beta-thromboglobulin, and platelet/endothelial cell adhesion molecule-1 when compared with myocardial infarction or angina patients without clinical depression.
Negative_regulation (exhibited) of platelet factor 4 in endothelial cell associated with acute coronary syndrome, angina, depression, myocardial infarction and adhesions
12) Confidence 0.01 Published 2003 Journal Blood Coagul. Fibrinolysis Section Abstract Doc Link 12960610 Disease Relevance 1.88 Pain Relevance 0.42
Surprisingly, patients with ACS and depression exhibited the highest levels of platelet factor 4, beta-thromboglobulin, and platelet/endothelial cell adhesion molecule-1 when compared with myocardial infarction or angina patients without clinical depression.
Negative_regulation (exhibited) of platelet factor 4 in platelet associated with acute coronary syndrome, angina, depression, myocardial infarction and adhesions
13) Confidence 0.00 Published 2003 Journal Blood Coagul. Fibrinolysis Section Abstract Doc Link 12960610 Disease Relevance 1.88 Pain Relevance 0.42

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