INT199411

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Context Info
Confidence 0.07
First Reported 2005
Last Reported 2005
Negated 0
Speculated 0
Reported most in Title
Documents 1
Total Number 1
Disease Relevance 0.08
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

isomerase activity (PPIG) protein folding (PPIG) nucleoplasm (PPIG)
nucleolus (PPIG) nucleus (PPIG) cytoplasm (PPIG)
PPIG (Homo sapiens)
Pain Link Frequency Relevance Heat
Versed 7 5.00 Very Low Very Low Very Low
rapifen 4 5.00 Very Low Very Low Very Low
carbamazepine 3 5.00 Very Low Very Low Very Low
cytokine 2 5.00 Very Low Very Low Very Low
lidocaine 2 5.00 Very Low Very Low Very Low
Paracetamol 2 5.00 Very Low Very Low Very Low
Potency 2 5.00 Very Low Very Low Very Low
Inflammation 1 5.00 Very Low Very Low Very Low
Bioavailability 1 5.00 Very Low Very Low Very Low
antagonist 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Toxicity 16 78.64 Quite High
Arrhythmia Under Development 3 5.00 Very Low Very Low Very Low
Hypertension 2 5.00 Very Low Very Low Very Low
Rhabdomyolysis 2 5.00 Very Low Very Low Very Low
Cv General 2 Under Development 2 5.00 Very Low Very Low Very Low
Death 1 5.00 Very Low Very Low Very Low
Breast Cancer 1 5.00 Very Low Very Low Very Low
Aging 1 5.00 Very Low Very Low Very Low
Injury 1 5.00 Very Low Very Low Very Low
Hepatotoxicity 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Clinical outcomes and management of mechanism-based inhibition of cytochrome P450 3A4

Mechanism-based inhibition of cytochrome P450 (CYP) 3A4 is characterized by NADPH-, time-, and concentration-dependent enzyme inactivation, occurring when some drugs are converted by CYPs to reactive metabolites.

Negative_regulation (inhibition) of Negative_regulation (inhibition) of CYP
1) Confidence 0.07 Published 2005 Journal Therapeutics and Clinical Risk Management Section Title Doc Link PMC1661603 Disease Relevance 0.08 Pain Relevance 0

General Comments

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