INT199422

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Context Info
Confidence 0.49
First Reported 2005
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 1.28
Pain Relevance 0.40

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (ABCB1) ATPase activity (ABCB1) plasma membrane (ABCB1)
transmembrane transport (ABCB1)
Anatomy Link Frequency
liver 2
ABCB1 (Homo sapiens)
Pain Link Frequency Relevance Heat
aspirin 2 95.52 Very High Very High Very High
cINOD 2 94.48 High High
methotrexate 4 92.96 High High
vincristine 2 78.80 Quite High
Bile 4 77.08 Quite High
ischemia 2 72.52 Quite High
Morphine 10 30.40 Quite Low
Analgesic 2 20.72 Low Low
Patient controlled alalgesia 4 11.28 Low Low
Bioavailability 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Injury 184 100.00 Very High Very High Very High
INFLAMMATION 6 94.24 High High
Adverse Drug Reaction 14 78.28 Quite High
Cv Unclassified Under Development 2 72.52 Quite High
Renal Disease 14 53.92 Quite High
Heart Rate Under Development 2 35.36 Quite Low
Critical Illness 14 29.56 Quite Low
Chronic Renal Failure 16 28.32 Quite Low
Hypoxia 4 27.40 Quite Low
Aging 11 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, this is more likely to be related to Pglycoprotein inhibition in the intestines than in the liver.
Positive_regulation (related) of Negative_regulation (inhibition) of Pglycoprotein in liver
1) Confidence 0.49 Published 2005 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC1661619 Disease Relevance 0.19 Pain Relevance 0
These observations indicate that AKI may result in a systemic suppression of P-gp function.
Positive_regulation (result) of Negative_regulation (suppression) of P-gp associated with injury
2) Confidence 0.01 Published 2008 Journal Crit Care Section Body Doc Link PMC2646335 Disease Relevance 0.24 Pain Relevance 0.12
The decreased activity of P-gp and OATs in AKI would contribute to decreased drug clearance and may potentially result in increased drug exposure.


Positive_regulation (contribute) of Negative_regulation (decreased) of P-gp associated with injury
3) Confidence 0.01 Published 2008 Journal Crit Care Section Body Doc Link PMC2646335 Disease Relevance 0.84 Pain Relevance 0.28

General Comments

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