INT19944

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Context Info
Confidence 0.58
First Reported 1989
Last Reported 2010
Negated 2
Speculated 0
Reported most in Abstract
Documents 39
Total Number 40
Disease Relevance 22.35
Pain Relevance 10.91

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (IFNG) extracellular region (IFNG)
Anatomy Link Frequency
monocytes 5
T-cell 4
PBMC 2
neutrophils 2
anterior 1
IFNG (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 78 100.00 Very High Very High Very High
Morphine 39 99.98 Very High Very High Very High
rheumatoid arthritis 10 99.84 Very High Very High Very High
abatacept 9 99.84 Very High Very High Very High
antidepressant 5 99.82 Very High Very High Very High
Inflammatory response 7 99.70 Very High Very High Very High
Multiple sclerosis 37 99.66 Very High Very High Very High
Neuritis 3 99.66 Very High Very High Very High
Pain 6 99.58 Very High Very High Very High
Inflammation 74 99.28 Very High Very High Very High
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 17 99.84 Very High Very High Very High
Colon Cancer 3 99.84 Very High Very High Very High
Demyelinating Disease 14 99.66 Very High Very High Very High
Experimental Autoimmune Neuritis 1 99.66 Very High Very High Very High
Takayasu Arteritis 100 99.64 Very High Very High Very High
INFLAMMATION 104 99.50 Very High Very High Very High
Acquired Immune Deficiency Syndrome Or Hiv Infection 27 99.48 Very High Very High Very High
Metastasis 1 99.48 Very High Very High Very High
Disease 115 99.28 Very High Very High Very High
Keloid Scars 15 99.12 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Morphine decreased the in vitro levels of interferon-gamma (IFN gamma) and IL-2 during single infections, and this effect was reversed by the addition of the opioid antagonist naloxone.
Negative_regulation (decreased) of IFN gamma associated with antagonist, narcan, opioid, infection and morphine
1) Confidence 0.58 Published 2003 Journal J. Acquir. Immune Defic. Syndr. Section Abstract Doc Link 12640199 Disease Relevance 1.38 Pain Relevance 1.00
Morphine decreased the in vitro levels of interferon-gamma (IFN gamma) and IL-2 during single infections, and this effect was reversed by the addition of the opioid antagonist naloxone.
Negative_regulation (decreased) of interferon-gamma associated with antagonist, narcan, opioid, infection and morphine
2) Confidence 0.58 Published 2003 Journal J. Acquir. Immune Defic. Syndr. Section Abstract Doc Link 12640199 Disease Relevance 1.37 Pain Relevance 0.99
Postoperatively, after cardiac surgery, an immunosuppression in the form of a polarization of T helper (Th) cells with a decreased Th1 response (IL-2 and IFN-gamma) and an increased Th2 response (IL-4 and IL-10) is recognized.
Negative_regulation (decreased) of IFN-gamma
3) Confidence 0.57 Published 2009 Journal Amino Acids Section Abstract Doc Link 18563517 Disease Relevance 0.06 Pain Relevance 0.07
Rolipram has a protective effect in experimental autoimmune neuritis associated with downregulation of interferon-gamma (IFN-?)
Negative_regulation (downregulation) of interferon-gamma associated with experimental autoimmune neuritis and neuritis
4) Confidence 0.57 Published 2009 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2695238 Disease Relevance 1.41 Pain Relevance 0.40
IL-18 immunoneutralization resulted in a 60-80% reduction of IL-1beta, IL-8, IFN-gamma, and TNF-alpha release from LPS-stimulated monocytes.
Negative_regulation (reduction) of IFN-gamma in monocytes
5) Confidence 0.57 Published 2000 Journal J. Immunol. Section Abstract Doc Link 11046058 Disease Relevance 0.15 Pain Relevance 0.31
IFN-gamma and TGF-beta may have opposing effects in MS, and treatments inhibiting IFN-gamma and/or promoting TGF-beta might ameliorate MS.
Negative_regulation (inhibiting) of IFN-gamma associated with multiple sclerosis
6) Confidence 0.54 Published 1994 Journal Ann. Neurol. Section Abstract Doc Link 8080246 Disease Relevance 1.05 Pain Relevance 0.61
Besides improved OS in patients with IFI, we also found a decrease in IFI-related mortality from 56.9% to 28.6% in the later period.
Negative_regulation (decrease) of IFI
7) Confidence 0.48 Published 2010 Journal Journal of Antimicrobial Chemotherapy Section Body Doc Link PMC2837550 Disease Relevance 0.56 Pain Relevance 0
The IFI-related mortality rate of 40.9% for the whole observation period was similar compared with earlier reports.7,25,27,28 A reduction in IFI-related mortality was also described in the recent literature,7,8,25 despite a significant increase in the incidence of IFI,7 comparing well with our results.
Negative_regulation (reduction) of IFI
8) Confidence 0.48 Published 2010 Journal Journal of Antimicrobial Chemotherapy Section Body Doc Link PMC2837550 Disease Relevance 0.52 Pain Relevance 0
In HSc tissues, IL-4 mRNA was increased, whereas, IFN-gamma mRNA was reduced compared with normal skin and mature scar.
Negative_regulation (reduced) of IFN-gamma in skin associated with cicatrix and keloid scars
9) Confidence 0.45 Published 2006 Journal J. Interferon Cytokine Res. Section Abstract Doc Link 16542140 Disease Relevance 1.91 Pain Relevance 0.27
Recent studies have shown that in vitro exposure of peripheral blood mononuclear cells (PBMC) to morphine results in suppressed respiratory-burst activity of monocytes and impaired interferon-gamma (IFN-gamma) production by lymphocytes.
Negative_regulation (impaired) of interferon-gamma in mononuclear cells associated with morphine
10) Confidence 0.43 Published 1989 Journal J. Infect. Dis. Section Abstract Doc Link 2536791 Disease Relevance 0 Pain Relevance 0.54
Prospective two-year followup of recombinant interferon-gamma in rheumatoid arthritis.
Negative_regulation (followup) of interferon-gamma associated with pain and rheumatoid arthritis
11) Confidence 0.43 Published 1990 Journal J. Rheumatol. Section Title Doc Link 2110252 Disease Relevance 0.46 Pain Relevance 0.29
Effective treatment of liver metastases from colon cancer with a combination of gamma-interferon and cisplatin chemotherapy: report of a case.
Negative_regulation (combination) of gamma-interferon in colon associated with colon cancer and metastasis
12) Confidence 0.43 Published 1995 Journal Surg. Today Section Title Doc Link 7633128 Disease Relevance 0.37 Pain Relevance 0.12
Morphine decreased the in vitro levels of interferon-gamma (IFN gamma) and IL-2 during single infections, and this effect was reversed by the addition of the opioid antagonist naloxone.
Negative_regulation (decreased) of IFN gamma associated with antagonist, narcan, opioid, infection and morphine
13) Confidence 0.42 Published 2003 Journal J. Acquir. Immune Defic. Syndr. Section Abstract Doc Link 12640199 Disease Relevance 1.38 Pain Relevance 1.00
In human peripheral blood mononuclear cells (PBMC), another group reported in two papers that interleukin-1 alpha (IL-1 alpha), tumor necrosis factor-alpha (TNF-alpha), interleukin-2 (IL-2), and interferon-gamma (IFN-gamma) at a protein and gene level in PBMC was increased after He-Ne irradiation at 18.9 J/cm2 and decreased with 37.8 J/cm2 [59,60].
Negative_regulation (decreased) of interferon-gamma in PBMC associated with necrosis and cancer
14) Confidence 0.42 Published 2010 Journal J Transl Med Section Body Doc Link PMC2830167 Disease Relevance 0.26 Pain Relevance 0
Our results demonstrated that exposing LPS-stimulated human monocytes to NCX-4016 resulted in a 40-80% inhibition of IL-1beta, IL-8, IL-12, IL-18, IFN-gamma, and TNF-alpha release with an EC(50) of 10-20 microM for IL-1beta and IL-18.
Negative_regulation (inhibition) of IFN-gamma in monocytes
15) Confidence 0.41 Published 2000 Journal J. Immunol. Section Abstract Doc Link 11046058 Disease Relevance 0.24 Pain Relevance 0.38
Anti-Inflammatory effects of antidepressants through suppression of the interferon-gamma/interleukin-10 production ratio.
Negative_regulation (suppression) of interferon-gamma associated with antidepressant and inflammation
16) Confidence 0.41 Published 2001 Journal J Clin Psychopharmacol Section Title Doc Link 11270917 Disease Relevance 0.64 Pain Relevance 0.69
Recombinant gamma interferon (rHuIFN-gamma) has been recognized to increase mRNA and protein levels of C1 inhibitor (C1 INH) in various human cells.
Negative_regulation (inhibitor) of rHuIFN-gamma
17) Confidence 0.41 Published 1994 Journal J. Lab. Clin. Med. Section Abstract Doc Link 8301199 Disease Relevance 0.35 Pain Relevance 0.06
These results can suggest a beneficial effect of IFN gamma when it is used as adjuvant in the treatment of tuberculosis patients that have resistance to standard chemotherapy, and encourage carrying out more extensive, controlled studies.
Negative_regulation (effect) of IFN gamma associated with mycobacterial infection
18) Confidence 0.41 Published 2004 Journal BMC Infect Dis Section Body Doc Link PMC529257 Disease Relevance 0.70 Pain Relevance 0.04
Anti-inflammatory and immunosuppressive treatment (e.g. with non-steroidal anti-inflammatory drugs or statins) may among other consequences, also contribute to a slow-down of the adverse effects of interferon-gamma.
Negative_regulation (slow-down) of interferon-gamma associated with inflammation and cinod
19) Confidence 0.41 Published 2006 Journal Curr Vasc Pharmacol Section Abstract Doc Link 16842138 Disease Relevance 1.02 Pain Relevance 0.15
It was found that immediately after rHuIFN-gamma treatment, tissue plasminogen activator activity and antigen levels were not significantly decreased in volunteers.
Neg (not) Negative_regulation (decreased) of rHuIFN-gamma
20) Confidence 0.40 Published 1994 Journal J. Lab. Clin. Med. Section Abstract Doc Link 8301199 Disease Relevance 0.51 Pain Relevance 0.07

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