INT199457

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Context Info
Confidence 0.23
First Reported 2005
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 1.68
Pain Relevance 0.44

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Gstp1) plasma membrane (Gstp1) nucleus (Gstp1)
intracellular (Gstp1) protein complex (Gstp1) cytoplasm (Gstp1)
Anatomy Link Frequency
neuronal 1
Gstp1 (Rattus norvegicus)
Gstp1 - I105V (1)
Pain Link Frequency Relevance Heat
Central nervous system 6 93.64 High High
Dopamine 46 91.44 High High
agonist 36 84.48 Quite High
Glutamate 9 79.72 Quite High
Paracetamol 1 61.92 Quite High
gABA 5 32.60 Quite Low
Neurotransmitter 7 26.36 Quite Low
Gabapentin 13 5.00 Very Low Very Low Very Low
sodium channel 12 5.00 Very Low Very Low Very Low
peripheral neuropathy 12 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Neuropathic Pain 30 99.32 Very High Very High Very High
Death 4 98.84 Very High Very High Very High
Parkinson's Disease 1 97.04 Very High Very High Very High
Apoptosis 2 92.84 High High
Drug Induced Neurotoxicity 53 86.80 High High
Toxicity 26 80.40 Quite High
Disease 14 76.96 Quite High
Colon Cancer 32 69.20 Quite High
Hepatotoxicity 1 63.36 Quite High
Cancer 6 54.20 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Gamelin et al. (17) did a study to find genetic variations involving oxalate metabolism and the glutathione cycle, but failed to prove an association between GSTP1 and oxaliplatin neuropathy.
GSTP1 Binding (association) of associated with neuropathic pain
1) Confidence 0.23 Published 2010 Journal Cancer Research and Treatment : Official Journal of Korean Cancer Association Section Body Doc Link PMC3021736 Disease Relevance 0.61 Pain Relevance 0
Four genetic variants (GSTP1 I105V, GSTM1 del, ERCC2 K751Q, XRCC1 R399Q) were tested for association with the time to development of grade 2/3 sensory neuropathy (sNT) and sNT as reason for treatment discontinuation.
GSTP1 I105V (I105V) Binding (association) of associated with neuropathic pain
2) Confidence 0.22 Published 2005 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC1661634 Disease Relevance 0.38 Pain Relevance 0
Furthermore, inhibition of GSTp increased DAergic neuronal cell death in Swiss-Webster rats treated with MPTP [65], a specific DAergic neurotoxin.
GSTp Neg (inhibition) Binding (inhibition) of in neuronal associated with parkinson's disease and death
3) Confidence 0.11 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2924890 Disease Relevance 0.69 Pain Relevance 0.44

General Comments

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