INT199483

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Context Info
Confidence 0.43
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.14
Pain Relevance 0.89

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleolus (Stat1) nucleus (Stat1) enzyme binding (Stat1)
DNA binding (Stat1) cytoplasm (Stat1)
Anatomy Link Frequency
nervous system 1
Stat1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Neuropeptide 5 98.90 Very High Very High Very High
Inflammation 73 88.16 High High
midbrain 2 87.20 High High
opioid receptor 94 82.00 Quite High
Analgesic 16 82.00 Quite High
Morphine 18 80.16 Quite High
Spinal cord 28 76.96 Quite High
Pain 39 62.52 Quite High
cytokine 7 61.20 Quite High
antinociception 37 58.68 Quite High
Disease Link Frequency Relevance Heat
Apoptosis 26 97.60 Very High Very High Very High
Nervous System Malformation 1 96.08 Very High Very High Very High
Neuroblastoma 1 93.00 High High
Targeted Disruption 4 92.40 High High
INFLAMMATION 84 88.16 High High
Pain 39 62.52 Quite High
Cancer 3 60.48 Quite High
Necrosis 2 60.00 Quite High
Osteoarthritis 1 35.64 Quite Low
Rheumatoid Arthritis 2 34.88 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Twelve of 16 of the other genes demonstrating a significant difference in expression regulate axonal branching (Nf1; [39]); are various neuropeptides/neuropeptide receptors (Hcrt, Npffr2, Npy1r, Npy, Ppyr1); regulate transcription (Fus, Stat1 and Zfp110); modulate cellular signalling (Frs2); regulate apoptosis (Tp53); or is involved with nervous system development (Fgfr1).
Transcription (transcription) of Stat1 in nervous system associated with nervous system malformation, neuropeptide and apoptosis
1) Confidence 0.43 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC3001741 Disease Relevance 0.29 Pain Relevance 0.13
IL-6 evoked increases in MOR expression are mediated by the transcription factors signal transducers and activators of transcription 1 (STAT1) and transcription 3 (STAT3) (Borner et al 2004).
Transcription (transcription) of STAT1
2) Confidence 0.19 Published 2005 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC1661636 Disease Relevance 0.85 Pain Relevance 0.76

General Comments

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