INT199489

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Context Info
Confidence 0.02
First Reported 2005
Last Reported 2005
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.85
Pain Relevance 0.68

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Stat6, Oprm1) signal transducer activity (Stat6, Oprm1) nucleolus (Stat6)
plasma membrane (Oprm1) nucleus (Stat6) DNA binding (Stat6)
Anatomy Link Frequency
neurons 1
Stat6 (Rattus norvegicus)
Oprm1 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 7 94.96 High High
Morphine 18 94.68 High High
Analgesic 16 93.80 High High
midbrain 2 91.16 High High
Nerve growth factor 5 79.68 Quite High
Inflammation 65 73.20 Quite High
opioid receptor 94 69.20 Quite High
Spinal cord 11 60.44 Quite High
dorsal root ganglion 11 57.68 Quite High
analgesia 56 50.00 Quite Low
Disease Link Frequency Relevance Heat
Cancer 3 94.24 High High
Necrosis 2 93.76 High High
Targeted Disruption 3 88.44 High High
Neuroblastoma 1 76.48 Quite High
INFLAMMATION 70 73.20 Quite High
Ganglion Cysts 12 57.68 Quite High
Nociception 9 53.20 Quite High
Pain 37 50.00 Quite Low
Neuropathic Pain 5 37.36 Quite Low
Osteoarthritis 1 19.12 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Interleukin-4 stimulates MOR transcription in cultured immune cells and cultured neurons via transcription 6 (STAT6) activation of the MOR gene promoter (Kraus et al 2001).
STAT6 Positive_regulation (activation) of MOR gene in neurons
1) Confidence 0.02 Published 2005 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC1661636 Disease Relevance 0.85 Pain Relevance 0.68

General Comments

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