INT19949

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Context Info
Confidence 0.60
First Reported 1987
Last Reported 2010
Negated 11
Speculated 5
Reported most in Abstract
Documents 36
Total Number 40
Disease Relevance 6.11
Pain Relevance 22.05

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

aging (Fos) nucleolus (Fos) nucleus (Fos)
DNA binding (Fos) transcription factor binding (Fos) response to stress (Fos)
Anatomy Link Frequency
brain 10
nucleus 6
dorsal horn 6
hippocampus 6
spinal cord 4
Fos (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Morphine 66 100.00 Very High Very High Very High
amygdala 51 100.00 Very High Very High Very High
antagonist 38 100.00 Very High Very High Very High
withdrawal 34 100.00 Very High Very High Very High
Opioid 24 100.00 Very High Very High Very High
narcan 24 100.00 Very High Very High Very High
fluoxetine 18 100.00 Very High Very High Very High
nMDA receptor 9 100.00 Very High Very High Very High
Endep 9 100.00 Very High Very High Very High
Intracerebroventricular 6 100.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Convulsion 9 100.00 Very High Very High Very High
Pressure And Volume Under Development 6 100.00 Very High Very High Very High
Overactive Bladder 3 100.00 Very High Very High Very High
Arthritis 2 100.00 Very High Very High Very High
Frailty 6 99.92 Very High Very High Very High
Stress 11 99.82 Very High Very High Very High
Inflammatory Pain 2 99.60 Very High Very High Very High
Nociception 23 98.92 Very High Very High Very High
Anaphylaxis 4 98.54 Very High Very High Very High
Pain 3 98.54 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Dorsomedial striatum and basolateral amygdaloid nucleus showed robust morphine-induced Fos protein induction that was unaffected by the pretreatments tested.
Neg (unaffected) Regulation (unaffected) of Positive_regulation (induction) of Fos in nucleus associated with morphine
1) Confidence 0.60 Published 2008 Journal Drug Alcohol Depend Section Abstract Doc Link 18485622 Disease Relevance 0.07 Pain Relevance 1.35
The present experiments were carried out to assess the effects of fluoxetine on c-fos induction throughout the rat brain.
Regulation (effects) of Positive_regulation (induction) of c-fos in brain associated with fluoxetine
2) Confidence 0.60 Published 1998 Journal Neuroscience Section Abstract Doc Link 9740405 Disease Relevance 0.10 Pain Relevance 0.52
We evaluated the effects of intracerebroventricular (i.c.v.) administration of beta-endorphin and naloxone, an opioid antagonist, on the induction of c-fos and corticotropin-releasing factor (CRF) mRNA to clarify the effects of beta-endorphin on cellular activity and CRF gene expression in the paraventricular nucleus (PVN) of the rat using in situ hybridization.
Regulation (effects) of in nucleus Positive_regulation (induction) of c-fos in PVN associated with antagonist, narcan, opioid and intracerebroventricular
3) Confidence 0.60 Published 1996 Journal Brain Res. Section Abstract Doc Link 8919295 Disease Relevance 0 Pain Relevance 0.35
The effect of hypertension on spinal induction of the c-fos proto-oncogene following noxious mechanical stimulation of the skin was studied in the rat.
Regulation (effect) of Positive_regulation (induction) of c-fos in skin associated with pressure and volume under development
4) Confidence 0.60 Published 1995 Journal Neuroreport Section Abstract Doc Link 8527737 Disease Relevance 0.43 Pain Relevance 0.07
Collectively these data give no support for a role for NO in the noxiously evoked induction of c-fos.
Regulation (role) of Positive_regulation (induction) of c-fos
5) Confidence 0.60 Published 2001 Journal Brain Res. Section Abstract Doc Link 11146065 Disease Relevance 0 Pain Relevance 0.09
We also studied the effect of CeA-injected DAMGO on LiCl-induced increases in c-Fos IR in the amygdala.
Regulation (effect) of Positive_regulation (increases) of c-Fos in CeA associated with amygdala
6) Confidence 0.60 Published 2004 Journal Brain Res. Section Abstract Doc Link 15223361 Disease Relevance 0 Pain Relevance 0.83
The influence of stimulus duration on spinal induction of the c-fos proto-oncogene was analysed in the rat by pinching or heating the skin for periods varying from 20 s to 2 h.
Regulation (influence) of Positive_regulation (induction) of c-fos in skin
7) Confidence 0.60 Published 1994 Journal Neuroreport Section Abstract Doc Link 7841361 Disease Relevance 0 Pain Relevance 0.06
A sensitization pretreatment schedule did, however, alter the c-fos expression patterns induced by all the drugs in the caudate putamen, nucleus accumbens, and the cerebral cortex.
Regulation (alter) of Positive_regulation (induced) of c-fos in cerebral cortex associated with nucleus accumbens and cerebral cortex
8) Confidence 0.60 Published 1996 Journal Neurochem. Res. Section Abstract Doc Link 8947933 Disease Relevance 0 Pain Relevance 0.39
Since many other substances which are related to pain mechanisms can be induced by Fos, it is suggested that nitric oxide may regulate production of these substances through activation of Fos.
Spec (may) Regulation (regulate) of Positive_regulation (activation) of Fos associated with pain
9) Confidence 0.45 Published 2000 Journal Neuroscience Section Abstract Doc Link 10683575 Disease Relevance 0.19 Pain Relevance 0.42
We examined the effects of systemically, spinally, and peripherally administered amitriptyline on formalin-induced Fos immunoreactivity in the lumbar spinal cord.
Spec (examined) Regulation (effects) of Positive_regulation (formalin-induced) of Fos in spinal cord associated with endep and spinal cord
10) Confidence 0.45 Published 2002 Journal Anesth. Analg. Section Abstract Doc Link 11812713 Disease Relevance 0 Pain Relevance 0.29
We examined the effects of fluoxetine on the induction of Fos-like proteins in Long-Evans and Sprague-Dawley rat brains.
Spec (examined) Regulation (effects) of Spec (examined) Positive_regulation (induction) of Fos in brains associated with fluoxetine
11) Confidence 0.45 Published 2002 Journal Neuroreport Section Abstract Doc Link 12499850 Disease Relevance 0.33 Pain Relevance 0.49
Considering the involvement of mesoaccumbens dopamine neurons and components of the 'extended amygdala' in motivated behavior and reward, it was hypothesized that the induction of c-Fos by naltrexone accounts for the motivational-affective consequences of opioid antagonism.
Regulation (accounts) of Positive_regulation (induction) of c-Fos in dopamine neurons associated with dopamine, opioid and amygdala
12) Confidence 0.44 Published 1999 Journal Brain Res. Section Abstract Doc Link 10082881 Disease Relevance 0 Pain Relevance 0.91
Previous data have shown that noxious thermal stimulation of the hind leg in the anesthetized rat causes c-fos activation in the paraventricular nucleus of the hypothalamus (PVN); in other brain nuclei, including the cathecholaminergic cell groups of the caudal medulla; and in the adenohypophysis.
Regulation (causes) of Positive_regulation (activation) of c-fos in hypothalamus associated with medulla
13) Confidence 0.44 Published 1999 Journal J. Comp. Neurol. Section Abstract Doc Link 10464375 Disease Relevance 0.26 Pain Relevance 0.07
The involvement of N-methyl-D-aspartate (NMDA) and alpha-amino-3-hydroxy-5-methylisoxazole-4-propionate (AMPA)/kainate (KA) receptors in the induction of c-Fos and Zif/268 expression in spinal dorsal horn neurons following noxious thermal or mechanical stimulation, or formalin injection into the rat hind paw was examined by intrathecal administration of a competitive NMDA receptor antagonist, 2-amino-5-phosphonopentanoic acid (APV) or an AMPA/KA receptor antagonist, 6-cyano-7-nitroquinoxaline-2,3-dione (CNQX), or both, 30 min prior to noxious stimulation.
Regulation (involvement) of Positive_regulation (induction) of c-Fos in dorsal horn associated with nmda receptor antagonist, antagonist, dorsal horn neuron and intrathecal
14) Confidence 0.44 Published 2002 Journal Neurosci. Res. Section Abstract Doc Link 12135782 Disease Relevance 0 Pain Relevance 0.26
On the contrary, c-fos induction in striatonigral neurons during withdrawal seems to involve a more complex regulation like opioid-dopamine interactions via the mu opioid receptor and the D1 dopamine receptor coexpressed on this neuronal population or the implication of other neurotransmitter systems.
Regulation (regulation) of Positive_regulation (induction) of c-fos in neuronal associated with neurotransmitter, dopamine, dopamine receptor, mu opioid receptor, opioid and withdrawal
15) Confidence 0.44 Published 2000 Journal Eur. J. Neurosci. Section Abstract Doc Link 11122358 Disease Relevance 0.13 Pain Relevance 1.21
Our results suggest that the phosphorylation of JNK is involved in the up-regulation of the proenkephalin gene expression via c-Fos and c-Jun that is induced by KA in rat hippocampus.
Regulation (involved) of Positive_regulation (up-regulation) of c-Fos in hippocampus associated with hippocampus
16) Confidence 0.44 Published 2001 Journal Mol. Cells Section Abstract Doc Link 11355693 Disease Relevance 0 Pain Relevance 0.27
Sexual dimorphism in the response to N-methyl-D-aspartate receptor antagonists and morphine on behavior and c-Fos induction in the rat brain.
Regulation (response) of Positive_regulation (induction) of c-Fos in brain associated with antagonist, nmda receptor and morphine
17) Confidence 0.44 Published 1999 Journal Neuroscience Section Title Doc Link 10501478 Disease Relevance 0 Pain Relevance 0.74
However, 6-cyano-7-nitroquinoxaline-2,3-dione (1 microM-1 mM) did not significantly affect induction of c-fos and zif268 by D1 receptor stimulation (SKF 38393, 2 mg/kg, i.p.) in the dopamine-depleted striatum.
Neg (not) Regulation (affect) of Positive_regulation (induction) of c-fos in striatum associated with dopamine
18) Confidence 0.44 Published 1999 Journal Neuroscience Section Abstract Doc Link 10077330 Disease Relevance 0 Pain Relevance 0.94
Restraint stress was not effective in c-Fos induction in the hippocampus of both sexes.
Neg (not) Regulation (effective) of Positive_regulation (induction) of c-Fos in hippocampus associated with stress and hippocampus
19) Confidence 0.44 Published 1997 Journal Neuroscience Section Abstract Doc Link 9330358 Disease Relevance 0.17 Pain Relevance 0.28
The stimulation had no effect on the c-fos inducibility at 2 days postinjury.
Neg (no) Regulation (effect) of Positive_regulation (inducibility) of c-fos
20) Confidence 0.44 Published 1997 Journal Neurosci. Res. Section Abstract Doc Link 9100258 Disease Relevance 0.54 Pain Relevance 0.22

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