INT199493

Context Info Confidence 0.05 First Reported 2005 Last Reported 2005 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 1.05 Pain Relevance 1.15

signal transduction (Ngf) extracellular space (Ngf) extracellular region (Ngf) plasma membrane (Oprd1) cytoplasm (Oprd1) signal transducer activity (Oprd1)

Ngf (Mus musculus) Oprd1 (Rattus norvegicus)

Pain Link Frequency Relevance Heat opioid receptor 94 100.00 Nerve growth factor 5 100.00 intrathecal 2 98.44 Opioid 127 97.44 Neuropathic pain 3 95.88 dorsal root ganglion 11 95.28 Inflammation 65 87.88 cytokine 7 84.80 Morphine 18 67.36 Analgesic 16 66.48

Disease Link Frequency Relevance Heat Nociception 9 97.84 Neuropathic Pain 5 95.88 Ganglion Cysts 12 95.28 Targeted Disruption 3 90.92 INFLAMMATION 70 87.88 Necrosis 2 77.44 Cancer 3 77.08 Pain 37 50.00 Neuroblastoma 1 49.16 Stress 18 5.00

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Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Further evidence that NGF influences opioid receptor function is provided by findings that intrathecal NGF restored opioid effectiveness in a rat model of neuropathic pain (Cahill, Dray, et al 2003).

NGF Regulation (influences) of opioid receptor associated with nerve growth factor, neuropathic pain, opioid receptor, opioid and intrathecal

1) Confidence 0.05 Published 2005 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC1661636 Disease Relevance 1.05 Pain Relevance 1.15

General Comments

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