INT199499

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Context Info
Confidence 0.01
First Reported 2005
Last Reported 2005
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.80
Pain Relevance 0.86

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Oprm1) extracellular space (Il6) extracellular region (Il6)
plasma membrane (Oprm1) signal transducer activity (Oprm1)
Il6 (Mus musculus)
Oprm1 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 65 99.50 Very High Very High Very High
opioid receptor 94 92.84 High High
Spinal cord 11 87.80 High High
Pain 38 73.36 Quite High
antinociception 37 69.52 Quite High
MU agonist 13 68.28 Quite High
midbrain 2 67.84 Quite High
Analgesic 16 62.64 Quite High
Morphine 18 60.80 Quite High
Opioid 127 59.88 Quite High
Disease Link Frequency Relevance Heat
INFLAMMATION 70 99.50 Very High Very High Very High
Neuroblastoma 1 98.80 Very High Very High Very High
Pain 37 73.36 Quite High
Targeted Disruption 3 73.04 Quite High
Osteoarthritis 1 46.48 Quite Low
Rheumatoid Arthritis 2 45.72 Quite Low
Cancer 3 41.12 Quite Low
Necrosis 2 40.64 Quite Low
Ganglion Cysts 12 25.88 Quite Low
Disease 6 7.60 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The inflammatory mediator interleukin-6 (IL-6) strongly induces MOR, but not DOR transcription and translation in the human neuroblastoma cell line SHSY5Y (Borner et al 2004).
IL-6 Positive_regulation (induces) of Transcription (transcription) of MOR associated with neuroblastoma and inflammation
1) Confidence 0.01 Published 2005 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC1661636 Disease Relevance 0.80 Pain Relevance 0.86

General Comments

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