INT19950

Context Info Confidence 0.16 First Reported 1990 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 13 Total Number 14 Disease Relevance 4.72 Pain Relevance 0.84

extracellular region (Abo) transferase activity, transferring glycosyl groups (Abo) Golgi apparatus (Abo) carbohydrate metabolic process (Abo)

Anatomy Link Frequency hepatocytes 1 saliva 1 Abo (Mus musculus)

Pain Link Frequency Relevance Heat Morphine 347 92.28 agonist 60 75.52 Bile 18 71.52 Nicotine 2 62.16 Hippocampus 8 58.56 Glutamate 2 34.52 Paracetamol 1 26.24 Opioid 57 18.32 Inflammation 54 5.00 Physical dependence 20 5.00

Disease Link Frequency Relevance Heat Sprains And Strains 284 98.48 Aging 20 97.04 Disease 87 91.44 Gastroenteritis 33 87.24 Apoptosis 57 86.20 Infection 49 85.40 Deafness 18 81.32 Atherosclerosis 9 77.68 Toxicity 2 67.88 Hypertension 2 66.16

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Anatomy

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The membrane-bound transferase expressed in yeast in glycosylated as indicated by its enhanced electrophoretic mobility in a SDS-polyacrylamide gel following endoglycosidase H treatment and detection by Western immunoblot analysis.

Gene_expression (expressed) of transferase

1) Confidence 0.16 Published 1990 Journal Biochemistry Section Abstract Doc Link 2110831 Disease Relevance 0.09 Pain Relevance 0.05

Consistent with the presence of mRNA, pUDPGTm-1c-transformed AH22 cells synthesize a transferase protein with Mr congruent to 51,000 by Western immunoblot analysis.

Gene_expression (synthesize) of transferase

2) Confidence 0.16 Published 1990 Journal Biochemistry Section Abstract Doc Link 2110831 Disease Relevance 0.09 Pain Relevance 0

Proteins with transferase activity, including methionine adenosyltransferase II, ?

Gene_expression (activity) of transferase

3) Confidence 0.12 Published 2007 Journal Genome Biol Section Body Doc Link PMC2394777 Disease Relevance 0.29 Pain Relevance 0.27

The truncated cDNA (lacking the putative membrane-insertion signal-peptide coding sequence, but with a newly adapted translation-start codon) is ligated into pAAH5 and is expressed as a cytosolic transferase form in the protease-deficient ZA521 strain of S. cerevisiae.

Gene_expression (expressed) of transferase associated with sprains and strains

4) Confidence 0.12 Published 1990 Journal Biochemistry Section Abstract Doc Link 2110831 Disease Relevance 0.15 Pain Relevance 0.09

In addition they measured the synthesis of AdoMet by adenosyl transferase and AdoMet utilization by COMT, and concluded that the decrease in AdoMet levels was a consequence of increased utilization during aging.

Gene_expression (utilization) of transferase associated with aging

5) Confidence 0.10 Published 2009 Journal Neurol Sci Section Body Doc Link PMC2746292 Disease Relevance 0.63 Pain Relevance 0.03

Expression of hypoxanthine guanine phosphoribosyl transferase 1 (Hprt1) transcript with a stable level between the strains and after the treatment was quantified to control for variation in cDNA amounts.

Gene_expression (Expression) of transferase associated with sprains and strains

6) Confidence 0.09 Published 2007 Journal Genome Biol Section Body Doc Link PMC2394777 Disease Relevance 0.10 Pain Relevance 0.06

T) and thus are incomplete nonsecretors, producing small amounts of ABO and Leb HBGA in secretions.

Gene_expression (amounts) of ABO

7) Confidence 0.08 Published 2010 Journal Emerging Infectious Diseases Section Body Doc Link PMC2874438 Disease Relevance 1.07 Pain Relevance 0

None of the nonsecretors who were also Lewis negative (n = 3), hence lacking the Lea antigen and ABO in saliva, were symptomatically infected.

Gene_expression (antigen) of ABO in saliva

8) Confidence 0.08 Published 2010 Journal Emerging Infectious Diseases Section Body Doc Link PMC2874438 Disease Relevance 0.49 Pain Relevance 0

Moreover, no statistical difference in susceptibility was found between persons of different Lewis or ABO phenotypes.

Gene_expression (phenotypes) of ABO

9) Confidence 0.07 Published 2010 Journal Emerging Infectious Diseases Section Abstract Doc Link PMC2874438 Disease Relevance 0.68 Pain Relevance 0

Using immunohistochemical techniques they showed that qualitative levels of super-oxide dismutase, glutamyl transferase and 4-hydroxynonenal increase between 3 month old and 9 month old B6 mice; and differ from the levels detected in age-matched, normal hearing CBA/CaJ mice.

Gene_expression (levels) of glutamyl transferase

10) Confidence 0.02 Published 2010 Journal J Occup Med Toxicol Section Body Doc Link PMC2868036 Disease Relevance 0.80 Pain Relevance 0

The A. paniculata ethanol extract, EtOAc extract and andrographolide induce the expression of the pi class of glutathione S-transferase, a phase II biotransformation enzymes involved in detoxification of various classes of environmental carcinogens, in rat primary hepatocytes [99].

Gene_expression (expression) of transferase in hepatocytes

11) Confidence 0.01 Published 2010 Journal Chin Med Section Body Doc Link PMC2881933 Disease Relevance 0.33 Pain Relevance 0.06

governs metabolism of amino acids by suppressing expression of genes involved in transamination (Aspartate amino transferase (Got1), Alanine amino transferase (Gpt), Alanine glyoxylate aminotransferase (Agtx2), and deamination (Glutaminase (Gls)), as well as numerous genes that are part of the urea cycle (Cps1, Otc, Ass1, and Asl) [160, 161, 245].

Gene_expression (expression) of Alanine amino transferase

12) Confidence 0.01 Published 2010 Journal PPAR Research Section Body Doc Link PMC2948931 Disease Relevance 0 Pain Relevance 0.14

governs metabolism of amino acids by suppressing expression of genes involved in transamination (Aspartate amino transferase (Got1), Alanine amino transferase (Gpt), Alanine glyoxylate aminotransferase (Agtx2), and deamination (Glutaminase (Gls)), as well as numerous genes that are part of the urea cycle (Cps1, Otc, Ass1, and Asl) [160, 161, 245].

Gene_expression (expression) of Aspartate amino transferase

13) Confidence 0.01 Published 2010 Journal PPAR Research Section Body Doc Link PMC2948931 Disease Relevance 0 Pain Relevance 0.14

Alternatively, it has been recently demonstrated that both yeast and human TERT can function as a template- and RNA-independent terminal transferase (TT) for DNA synthesis in the presence of Mn2+ [90].

Gene_expression (synthesis) of transferase

14) Confidence 0.01 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2561060 Disease Relevance 0 Pain Relevance 0

General Comments

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