INT199521

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Context Info
Confidence 0.96
First Reported 2006
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.39
Pain Relevance 0.15

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (PKD1) nucleus (PKD1) cilium (PKD1)
cytoplasm (PKD1)
Anatomy Link Frequency
cleavage 1
PKD1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Potency 6 95.52 Very High Very High Very High
Inflammation 1 56.72 Quite High
Mechanotransduction 1 16.08 Low Low
Bioavailability 3 5.00 Very Low Very Low Very Low
TRP channel 2 5.00 Very Low Very Low Very Low
adenocard 2 5.00 Very Low Very Low Very Low
member 8 1 5.00 Very Low Very Low Very Low
Parenteral administration 1 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hypercalcemia 10 85.20 High High
Osteoporotic Fractures 4 70.04 Quite High
Osteoporosis 15 61.44 Quite High
Organ Transplantation 1 58.92 Quite High
INFLAMMATION 1 56.72 Quite High
Disease 12 54.48 Quite High
Polycystic Kidney Disease 8 50.00 Quite Low
Aging 2 44.20 Quite Low
Toxicity 4 5.00 Very Low Very Low Very Low
Autosomal Dominant Polycystic Kidney 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Bisphosphonates are pyrophosphate analogs which contain a phosphate-carbon-phosphate (P-C-P) core structure that targets them to bone and renders them resistant to enzymatic degradation.
Protein_catabolism (degradation) of P-C
1) Confidence 0.96 Published 2006 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC1661643 Disease Relevance 0.39 Pain Relevance 0.15
In addition to a putative function in making SpREJ and PKD1 proteins capable of great elasticity, the REJ domain is also known to be required for cleavage of hPKD1 in the GPS domain, a process necessary to make a functional hPKD1 [28].
Protein_catabolism (cleavage) of hPKD1 in cleavage
2) Confidence 0.40 Published 2007 Journal BMC Genomics Section Body Doc Link PMC1934368 Disease Relevance 0 Pain Relevance 0

General Comments

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