INT199548

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Context Info
Confidence 0.08
First Reported 2006
Last Reported 2006
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.30
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

tk (Mus musculus)
Pain Link Frequency Relevance Heat
Central nervous system 4 5.00 Very Low Very Low Very Low
palliative 1 5.00 Very Low Very Low Very Low
cytokine 1 5.00 Very Low Very Low Very Low
Kinase C 1 5.00 Very Low Very Low Very Low
adenocard 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Melanoma 3 91.96 High High
Renal Cell Carcinoma 50 73.32 Quite High
Cancer 29 68.84 Quite High
Adenocarcinoma 2 34.32 Quite Low
Non-small-cell Lung Cancer 6 26.00 Quite Low
Disease 31 10.28 Low Low
Breast Cancer 2 7.20 Low Low
Gastrointestinal Stromal Tumor 2 6.24 Low Low
Toxicity 19 5.00 Very Low Very Low Very Low
Metastasis 8 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In cell-free biochemical assays, varying concentrations of sorafenib were assayed for their capacity to inhibit phosphorylation of the non-receptor TK mitogen-activated protein kinase kinase (MEK) by the catalytic domains of BRAF and V600E BRAF (Wilhelm et al 2004).
Negative_regulation (inhibit) of Phosphorylation (phosphorylation) of TK
1) Confidence 0.08 Published 2006 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC1661649 Disease Relevance 0.30 Pain Relevance 0

General Comments

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