INT199549

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Context Info
Confidence 0.16
First Reported 2006
Last Reported 2006
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.90
Pain Relevance 0.08

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

tk (Mus musculus)
Pain Link Frequency Relevance Heat
Kinase C 2 82.40 Quite High
adenocard 2 78.56 Quite High
Central nervous system 8 5.00 Very Low Very Low Very Low
palliative 2 5.00 Very Low Very Low Very Low
cytokine 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Melanoma 6 91.64 High High
Metastasis 16 90.00 High High
Hyperplasia 4 88.40 High High
Cancer 58 86.68 High High
Renal Cell Carcinoma 100 73.00 Quite High
Chronic Myeloid Leukemia 2 57.36 Quite High
Myeloid Leukemia 4 54.96 Quite High
Disease 62 52.28 Quite High
Genetic Translocation 2 51.44 Quite High
Toxicity 38 49.52 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Ligand-binding induces autophosphorylation of the cytoplasmic domain, conformational changes, and increased TK activity.
Phosphorylation (autophosphorylation) of TK
1) Confidence 0.16 Published 2006 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC1661649 Disease Relevance 0.60 Pain Relevance 0.08
In cell-free biochemical assays, varying concentrations of sorafenib were assayed for their capacity to inhibit phosphorylation of the non-receptor TK mitogen-activated protein kinase kinase (MEK) by the catalytic domains of BRAF and V600E BRAF (Wilhelm et al 2004).
Phosphorylation (phosphorylation) of TK
2) Confidence 0.15 Published 2006 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC1661649 Disease Relevance 0.30 Pain Relevance 0

General Comments

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