INT199550

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Context Info
Confidence 0.37
First Reported 2006
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 18
Total Number 19
Disease Relevance 12.57
Pain Relevance 1.37

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Flt1) endosome (Flt1) Golgi apparatus (Flt1)
plasma membrane (Flt1) nucleus (Flt1) kinase activity (Flt1)
Anatomy Link Frequency
epithelial cell 2
endothelial cells 2
macrophage 1
interstitial cells 1
alveolar macrophages 1
Flt1 (Mus musculus)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 114 98.80 Very High Very High Very High
Inflammation 85 98.28 Very High Very High Very High
Arthritis 16 88.40 High High
cytokine 27 85.24 High High
chemokine 9 74.48 Quite High
antagonist 12 72.52 Quite High
metalloproteinase 6 65.44 Quite High
Bioavailability 1 56.64 Quite High
ischemia 70 53.72 Quite High
Inflammatory response 41 51.88 Quite High
Disease Link Frequency Relevance Heat
Fibromyalgia 3 100.00 Very High Very High Very High
Retinal Neovascularization 2 99.70 Very High Very High Very High
Hypoxia 78 99.68 Very High Very High Very High
Death 177 99.60 Very High Very High Very High
Myelodysplastic Syndromes 42 99.20 Very High Very High Very High
Rheumatoid Arthritis 116 98.80 Very High Very High Very High
INFLAMMATION 127 98.28 Very High Very High Very High
Hyperoxia 49 98.24 Very High Very High Very High
Pre-eclampsia 72 97.90 Very High Very High Very High
Nervous System Injury 1 96.72 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Considering that Flt-1 tyrosine kinase signaling promotes RA via monocyte/macrophage activation [31, 40], the selective inhibition of Flt-1 may be effective at blocking VEGF-induced inflammation and angiogenesis with minimal toxicity.
Negative_regulation (inhibition) of Flt-1 in macrophage associated with toxicity, inflammation and rheumatoid arthritis
1) Confidence 0.37 Published 2008 Journal Mediators of Inflammation Section Body Doc Link PMC2638142 Disease Relevance 1.43 Pain Relevance 0.46
Mice deficient in VEGFR1 (e.g., VEGFR1?
Negative_regulation (deficient) of VEGFR1
2) Confidence 0.37 Published 2010 Journal Journal of Oncology Section Body Doc Link PMC2902148 Disease Relevance 0.29 Pain Relevance 0.06
We noted at day 7 a reduced level of VEGFR1.
Negative_regulation (reduced) of VEGFR1
3) Confidence 0.35 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2866363 Disease Relevance 1.23 Pain Relevance 0.18
The same result was also observed in cultured endothelial cells in vitro [14] and in animal models with retinal neovascularization [13], whereby suppression of Vegfr2 but not Vegfr1 reduced the ability of VEGF to induce vasohibin-1.
Negative_regulation (suppression) of Vegfr1 in endothelial cells associated with retinal neovascularization
4) Confidence 0.33 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2913137 Disease Relevance 0.54 Pain Relevance 0
The decreased expression level of VEGFR-1 was more significant in the IIR group (p < 0.01).
Negative_regulation (decreased) of VEGFR-1
5) Confidence 0.31 Published 2006 Journal Crit Care Section Body Doc Link PMC1751039 Disease Relevance 0.41 Pain Relevance 0
Although such an effect has not been shown in endothelial cells, one could assume that VEGFR1 phosphorylation blockade would have a direct antiangiogenic effect.
Negative_regulation (blockade) of VEGFR1 in endothelial cells
6) Confidence 0.29 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2883966 Disease Relevance 0.80 Pain Relevance 0
The protein levels of VEGF or VEGFR-1 were reduced by siRNA treatment, as confirmed by immunofluorescent staining (Figure 6c) and western blotting (Figure 6d) with specific antibodies against VEGF or VEGFR-1, respectively.
Negative_regulation (reduced) of VEGFR-1
7) Confidence 0.22 Published 2006 Journal Crit Care Section Body Doc Link PMC1751039 Disease Relevance 0.20 Pain Relevance 0
When human lung epithelial A549 cells were pre-treated with 50 nM of siRNA either against VEGF or VEGFR-1 for 24 hours, reduced VEGF and VEGFR-1 levels were associated with reduced cell viability.


Negative_regulation (reduced) of VEGFR-1 in A549
8) Confidence 0.22 Published 2006 Journal Crit Care Section Abstract Doc Link PMC1751039 Disease Relevance 0.64 Pain Relevance 0.09
The significant negative correlation between VEGFR-1 positive cells and epithelial cell death suggests that down-regulation of VEGFR-1 may be due to epithelial cell death.
Negative_regulation (regulation) of VEGFR-1 in epithelial cell associated with death
9) Confidence 0.22 Published 2006 Journal Crit Care Section Body Doc Link PMC1751039 Disease Relevance 0.48 Pain Relevance 0
The decrease of VEGFR-1 positive cells was more significant in the IIR group (p < 0.01), due to the reduced staining on type I epithelial cells, interstitial cells and alveolar macrophages (Figure 3, Table 2).


Negative_regulation (decrease) of VEGFR-1 in epithelial cells
10) Confidence 0.22 Published 2006 Journal Crit Care Section Body Doc Link PMC1751039 Disease Relevance 0 Pain Relevance 0
Therapy with this inhibitor of several protein-tyrosine kinases, including ABL, PDGFR, KIT and FMS tyrosine kinase, has been proposed.
Negative_regulation (inhibitor) of FMS tyrosine kinase associated with fibromyalgia
11) Confidence 0.19 Published 2007 Journal Intern Emerg Med Section Body Doc Link PMC2780604 Disease Relevance 0.87 Pain Relevance 0.04
Semaxinib (SU5416), an inhibitor of the VEGFR1 and VEGFR2 TKs, has also been studied in combination with INF-?
Negative_regulation (inhibitor) of VEGFR1
12) Confidence 0.18 Published 2006 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC1661649 Disease Relevance 0.73 Pain Relevance 0
Elevated expression of several genes known to be sensitive to hypoxia and/or glucose deprivation (Pfkfb3, Vegfc, Flt1 and Trib3), suggest that elevated expression of Gadd45 may be due to these factors and that 4T1 cells exist in a state of stress or pseudo-stress even under optimal culture conditions.


Negative_regulation (deprivation) of Flt1 in 4T1 associated with stress and hypoxia
13) Confidence 0.16 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2529338 Disease Relevance 0.63 Pain Relevance 0.07
To determine expression of those proteins, as well as their target genes VEGF and VEGFR-1/2, immunoblotting was performed (Figure 5) and densitometry data are summarized in Table 2.
Spec (determine) Negative_regulation (determine) of VEGFR-1/2
14) Confidence 0.15 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2603310 Disease Relevance 0.86 Pain Relevance 0
Considering that Flt-1 tyrosine kinase signaling promotes RA via monocyte/macrophage activation [31, 40], the selective inhibition of Flt-1 may be effective at blocking VEGF-induced inflammation and angiogenesis with minimal toxicity.
Negative_regulation (inhibition) of Flt-1 in monocyte associated with toxicity, inflammation and rheumatoid arthritis
15) Confidence 0.13 Published 2008 Journal Mediators of Inflammation Section Body Doc Link PMC2638142 Disease Relevance 1.43 Pain Relevance 0.46
Furthermore, antiangiogenic effects could be observed in both studies with a reduced microvessel density and altered expression levels of angiogenesis-related factors like FLT-1, Neuropillin-2 and VEGF-C, respectively [97, 98].
Negative_regulation (reduced) of FLT-1
16) Confidence 0.11 Published 2010 Journal Journal of Oncology Section Body Doc Link PMC2871186 Disease Relevance 1.35 Pain Relevance 0
The decrease of VEGFR-1 positive cells was more significant in the IIR group (p < 0.01), due to the reduced staining on type I epithelial cells, interstitial cells and alveolar macrophages (Figure 3, Table 2).


Negative_regulation (decrease) of VEGFR-1 in interstitial cells
17) Confidence 0.08 Published 2006 Journal Crit Care Section Body Doc Link PMC1751039 Disease Relevance 0 Pain Relevance 0
The decrease of VEGFR-1 positive cells was more significant in the IIR group (p < 0.01), due to the reduced staining on type I epithelial cells, interstitial cells and alveolar macrophages (Figure 3, Table 2).


Negative_regulation (decrease) of VEGFR-1 in alveolar macrophages
18) Confidence 0.08 Published 2006 Journal Crit Care Section Body Doc Link PMC1751039 Disease Relevance 0 Pain Relevance 0
Thus pravastatin may prevent PE-specific features by restoring angiogenesis and placental development through two different mechanisms: decreasing sFlt-1 levels and increasing VEGF levels.
Negative_regulation (decreasing) of sFlt-1 associated with pre-eclampsia
19) Confidence 0.06 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2965104 Disease Relevance 0.66 Pain Relevance 0

General Comments

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