INT199554

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Context Info
Confidence 0.01
First Reported 2006
Last Reported 2006
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.54
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Tnk1) kinase activity (Tnk1) cytoplasm (Tnk1)
Anatomy Link Frequency
liver 1
Tnk1 (Mus musculus)
Pain Link Frequency Relevance Heat
Central nervous system 4 5.00 Very Low Very Low Very Low
palliative 1 5.00 Very Low Very Low Very Low
cytokine 1 5.00 Very Low Very Low Very Low
Kinase C 1 5.00 Very Low Very Low Very Low
adenocard 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Renal Cell Carcinoma 50 95.80 Very High Very High Very High
Cancer 29 91.32 High High
Melanoma 3 75.60 Quite High
Adenocarcinoma 2 56.80 Quite High
Non-small-cell Lung Cancer 6 48.48 Quite Low
Disease 31 32.76 Quite Low
Gastrointestinal Stromal Tumor 2 28.72 Quite Low
Myeloid Leukemia 2 25.76 Quite Low
Disease Progression 3 14.60 Low Low
Toxicity 19 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In addition to inhibition of Raf family non-receptor kinases, sorafenib also inhibits a number of receptor TKs in cell-free assays known to be involved in angiogenesis and tumorigenesis such as VEGFR2, VEGFR3, fetal liver tyrosine kinase 3 (Flt-3), c-KIT, and PDGFR.
Negative_regulation (inhibition) of non-receptor in liver
1) Confidence 0.01 Published 2006 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC1661649 Disease Relevance 0.54 Pain Relevance 0

General Comments

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