INT199560

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.30
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 13
Disease Relevance 8.83
Pain Relevance 4.80

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Braf) plasma membrane (Braf) nucleus (Braf)
kinase activity (Braf) cytoplasm (Braf)
Braf (Mus musculus)
Braf - V600E (1)
Pain Link Frequency Relevance Heat
melanocortin 1 receptor 33 100.00 Very High Very High Very High
rheumatoid arthritis 740 99.84 Very High Very High Very High
cytokine 52 97.24 Very High Very High Very High
Inflammation 70 96.84 Very High Very High Very High
spinal inflammation 100 91.76 High High
Arthritis 100 90.60 High High
Kinase C 12 85.84 High High
psoriasis 20 35.28 Quite Low
Glutamate 10 15.24 Low Low
Central nervous system 8 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Sarcoma 30 100.00 Very High Very High Very High
Rheumatoid Arthritis 740 99.84 Very High Very High Very High
Melanoma 8 99.12 Very High Very High Very High
INFLAMMATION 50 96.84 Very High Very High Very High
Skin Cancer 49 93.76 High High
Arthritis 120 92.04 High High
Low Back Pain 100 91.76 High High
Cancer 77 86.60 High High
Arthropathy 10 72.12 Quite High
Breast Cancer 5 63.36 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We identified two linear peptides on BRAF, P10 and P25, recognized preferentially by RA patients.
BRAF Binding (recognized) of associated with rheumatoid arthritis
1) Confidence 0.30 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2991030 Disease Relevance 1.16 Pain Relevance 0.62
We have observed that sera from RA patients recognize the BRAF's catalytic domain which encompasses amino acids 416 to 766.
BRAF Binding (recognize) of associated with rheumatoid arthritis
2) Confidence 0.30 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2991030 Disease Relevance 0.73 Pain Relevance 0.42
Because the association between MC1R variation and BRAF was most apparent in melanomas without evidence of chronic sun damage, Landi et al. hypothesized that UV radiation acted indirectly to promote BRAF-mutant melanoma, which is also consistent with our findings.
BRAF Binding (association) of associated with melanocortin 1 receptor, melanoma and skin cancer
3) Confidence 0.28 Published 2007 Journal PLoS Genetics Section Body Doc Link PMC1774588 Disease Relevance 0.75 Pain Relevance 0.42
BRAF kinase assay
BRAF kinase Binding (assay) of
4) Confidence 0.26 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2991030 Disease Relevance 0.09 Pain Relevance 0.05
To test whether autoantibodies to BRAF influence BRAF kinase activity, we developed a phosphorylation assay with BRAF, its substrate MEK1 and purified anti-BRAF autoantibodies from RA patients.
BRAF kinase Binding (activity) of associated with rheumatoid arthritis
5) Confidence 0.26 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2991030 Disease Relevance 0.91 Pain Relevance 0.52
By screening protein arrays, we found that BRAF (v raf murine sarcoma viral oncogene homologue B1) is a major non-itrullinated autoantigen recognized by 35% of RA patients' sera [8].
BRAF Binding (recognized) of associated with sarcoma and rheumatoid arthritis
6) Confidence 0.25 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2991030 Disease Relevance 0.95 Pain Relevance 0.46
Sorafenib has been co-crystallized in complex with BRAF and V600E BRAF (Wan et al 2004).
BRAF Binding (complex) of
7) Confidence 0.23 Published 2006 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC1661649 Disease Relevance 0.13 Pain Relevance 0
To test whether autoantibodies to BRAF may influence BRAF activity as a kinase, we developed a phosphorylation assay using BRAF, MEK1 (its major substrate) and autoantibodies to BRAF purified from RA patients' sera.
BRAF Binding (using) of associated with rheumatoid arthritis
8) Confidence 0.23 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2991030 Disease Relevance 0.79 Pain Relevance 0.49
To test whether autoantibodies to BRAF may influence BRAF activity as a kinase, we developed a phosphorylation assay using BRAF, MEK1 (its major substrate) and autoantibodies to BRAF purified from RA patients' sera.
BRAF Binding (using) of associated with rheumatoid arthritis
9) Confidence 0.23 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2991030 Disease Relevance 0.81 Pain Relevance 0.50
We found that one BRAF peptide, P25 (656 to 675), is specifically recognized by autoantibodies from RA patients.
BRAF Binding (recognized) of associated with rheumatoid arthritis
10) Confidence 0.23 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2991030 Disease Relevance 0.83 Pain Relevance 0.46
Peptide P25 on BRAF is specifically recognized by RA patients
BRAF Binding (recognized) of associated with rheumatoid arthritis
11) Confidence 0.23 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2991030 Disease Relevance 1.02 Pain Relevance 0.59
We have observed that sera from rheumatoid arthritis (RA) patients recognize the BRAF's catalytic domain, which encompasses amino acids 416 to 766.
BRAF Binding (recognize) of associated with rheumatoid arthritis
12) Confidence 0.22 Published 2010 Journal Arthritis Res Ther Section Abstract Doc Link PMC2991030 Disease Relevance 0.55 Pain Relevance 0.28
Sorafenib has been co-crystallized in complex with BRAF and V600E BRAF (Wan et al 2004).
V600E BRAF (V600E) Binding (complex) of
13) Confidence 0.20 Published 2006 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC1661649 Disease Relevance 0.13 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox