INT199562

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Context Info
Confidence 0.31
First Reported 2006
Last Reported 2006
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.25
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Braf) plasma membrane (Braf) nucleus (Braf)
kinase activity (Braf) cytoplasm (Braf)
Braf (Mus musculus)
Braf - V600E (1)
Pain Link Frequency Relevance Heat
Central nervous system 8 5.00 Very Low Very Low Very Low
palliative 2 5.00 Very Low Very Low Very Low
cytokine 2 5.00 Very Low Very Low Very Low
Kinase C 2 5.00 Very Low Very Low Very Low
adenocard 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Melanoma 6 63.96 Quite High
Breast Cancer 4 63.36 Quite High
Renal Cell Carcinoma 100 50.00 Quite Low
Cancer 58 40.84 Quite Low
Pancreatic Cancer 2 40.08 Quite Low
Colon Cancer 4 36.40 Quite Low
Small Cell Lung Cancer 4 16.56 Low Low
Adenocarcinoma 4 6.32 Low Low
Disease 62 5.00 Very Low Very Low Very Low
Toxicity 38 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Sorafenib has been co-crystallized in complex with BRAF and V600E BRAF (Wan et al 2004).
Positive_regulation (crystallized) of BRAF Binding (complex) of
1) Confidence 0.31 Published 2006 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC1661649 Disease Relevance 0.13 Pain Relevance 0
Sorafenib has been co-crystallized in complex with BRAF and V600E BRAF (Wan et al 2004).
Positive_regulation (crystallized) of V600E BRAF (V600E) Binding (complex) of
2) Confidence 0.27 Published 2006 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC1661649 Disease Relevance 0.13 Pain Relevance 0

General Comments

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