INT199566

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Context Info
Confidence 0.39
First Reported 2006
Last Reported 2009
Negated 1
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 3.06
Pain Relevance 0.31

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
ACN 2
Atlas 2
tk (Mus musculus)
Pain Link Frequency Relevance Heat
Kinase C 2 83.88 Quite High
imagery 34 74.60 Quite High
Electroencephalography 1 66.00 Quite High
adenocard 2 49.52 Quite Low
Central nervous system 10 5.00 Very Low Very Low Very Low
Nav1.7 10 5.00 Very Low Very Low Very Low
Pain 9 5.00 Very Low Very Low Very Low
Paroxysmal extreme pain disorder 7 5.00 Very Low Very Low Very Low
primary erythermalgia 5 5.00 Very Low Very Low Very Low
sodium channel 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Genetic Translocation 2 99.72 Very High Very High Very High
Malignant Neoplastic Disease 2 99.64 Very High Very High Very High
Sprains And Strains 63 97.24 Very High Very High Very High
Myeloid Leukemia 4 97.08 Very High Very High Very High
Chronic Myeloid Leukemia 2 96.88 Very High Very High Very High
Renal Cell Carcinoma 100 96.64 Very High Very High Very High
Convulsion 72 93.00 High High
Cancer 58 92.88 High High
Mycobacterial Infection 98 91.44 High High
Febrile Convulsions 60 76.44 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
High levels of tk expression by the Phsp60 could possibly be toxic to the mycobacteria, though this was not observed in this study.
Positive_regulation (levels) of Gene_expression (expression) of tk
1) Confidence 0.39 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2706987 Disease Relevance 0.89 Pain Relevance 0.20
Briefly, the following changes were introduced into the wild-type Scn9a (Figure 2A): the p.N641Y mutation into exon 11, the ACN positive selection vector into intron 10, and the negative TK selection vector into intron 12 (Figure 2B).
Positive_regulation (negative) of Neg (negative) Gene_expression (introduced) of TK in ACN
2) Confidence 0.13 Published 2009 Journal PLoS Genetics Section Body Doc Link PMC2730533 Disease Relevance 0.67 Pain Relevance 0.03
A second mechanism of TK dysfunction in malignant cells is via the overexpression of a TK or its ligand; eg, the overexpression of VEGFR, PDGFR, or EGFR or their ligands in RCC (Gomella et al 1989; Mydlo et al 1989; Atlas et al 1992; Uhlman et al 1995; Iliopoulos et al 1996; Ramp et al 2000; Gunningham et al 2001; Na et al 2003; Sulzbacher et al 2003, Yildiz et al 2004; Minardi et al 2005; Xu et al 2005).
Positive_regulation (overexpression) of Gene_expression (overexpression) of TK in Atlas associated with malignant neoplastic disease and renal cell carcinoma
3) Confidence 0.10 Published 2006 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC1661649 Disease Relevance 0.77 Pain Relevance 0.04
This causes the production of the nonreceptor TK BCR–ABL fusion protein.
Positive_regulation (causes) of Gene_expression (production) of TK
4) Confidence 0.09 Published 2006 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC1661649 Disease Relevance 0.73 Pain Relevance 0.04

General Comments

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