INT199571

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Context Info
Confidence 0.23
First Reported 2006
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 3.40
Pain Relevance 0.07

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Vhl) mitochondrion (Vhl) nucleus (Vhl)
extracellular matrix organization (Vhl) cytoplasm (Vhl)
Vhl (Mus musculus)
Pain Link Frequency Relevance Heat
Central nervous system 7 68.76 Quite High
palliative 2 35.76 Quite Low
Inflammation 20 5.00 Very Low Very Low Very Low
COX2 7 5.00 Very Low Very Low Very Low
cva 4 5.00 Very Low Very Low Very Low
cytokine 3 5.00 Very Low Very Low Very Low
withdrawal 2 5.00 Very Low Very Low Very Low
chemokine 2 5.00 Very Low Very Low Very Low
Spinal cord 1 5.00 Very Low Very Low Very Low
ketamine 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hypoxia 33 99.84 Very High Very High Very High
Cancer 75 99.72 Very High Very High Very High
Renal Cancer 86 89.12 High High
Renal Cell Carcinoma 50 83.28 Quite High
Disease 45 80.40 Quite High
Von Hippel-lindau Syndrome 1 79.08 Quite High
Respiratory Syncytial Virus 99 75.08 Quite High
Infection 89 74.72 Quite High
Carcinoma 4 69.80 Quite High
Hemangioblastoma 1 66.92 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, the formation of VHL protein complexes is suppressed when cells become hypoxic, allowing HIF?
VHL Binding (complexes) of associated with hypoxia
1) Confidence 0.23 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2721410 Disease Relevance 1.64 Pain Relevance 0
Under normoxic conditions, the VHL protein is bound to hypoxia inducible factor-1?
VHL Binding (bound) of associated with hypoxia
2) Confidence 0.18 Published 2006 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC1661649 Disease Relevance 1.18 Pain Relevance 0.07
The modification is required for the binding of the von Hippel-Lindau (VHL) tumor suppressor protein, the recognition component of an E3 ubiquitin-protein ligase that targets HIF-1?
Hippel-Lindau Binding (binding) of associated with cancer
3) Confidence 0.02 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2556398 Disease Relevance 0.58 Pain Relevance 0

General Comments

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