INT199583

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Context Info
Confidence 0.26
First Reported 2006
Last Reported 2006
Negated 1
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 1.39
Pain Relevance 0.11

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (HIF1A, Vhl) nucleus (HIF1A, Vhl) cell differentiation (HIF1A)
mitochondrion (Vhl) extracellular matrix organization (Vhl) signal transducer activity (HIF1A)
HIF1A (Homo sapiens)
Vhl (Mus musculus)
Pain Link Frequency Relevance Heat
Central nervous system 4 60.48 Quite High
palliative 1 53.44 Quite High
cytokine 1 5.00 Very Low Very Low Very Low
Kinase C 1 5.00 Very Low Very Low Very Low
adenocard 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hypoxia 3 99.56 Very High Very High Very High
Hyperplasia 2 83.92 Quite High
Renal Cell Carcinoma 50 78.64 Quite High
Von Hippel-lindau Syndrome 1 70.80 Quite High
Disease 31 67.60 Quite High
Cancer 29 66.40 Quite High
Carcinoma 3 61.52 Quite High
Hemangioblastoma 1 58.64 Quite High
Recurrence 5 58.32 Quite High
Metastasis 8 51.24 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In hypoxic conditions or in the absence of VHL, HIF-1a accumulates, stimulating the production of growth factors such as vascular endothelial growth factor (VEGF), transforming growth factor a (TGF?)
HIF-1a Positive_regulation (accumulates) of Neg (absence) Gene_expression (absence) of VHL associated with hypoxia
1) Confidence 0.26 Published 2006 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC1661649 Disease Relevance 1.39 Pain Relevance 0.11

General Comments

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