INT199601

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Context Info
Confidence 0.50
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 9
Total Number 12
Disease Relevance 6.13
Pain Relevance 1.22

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (FGF7) extracellular space (FGF7) extracellular region (FGF7)
Golgi apparatus (FGF7)
Anatomy Link Frequency
epithelial cells 3
mammary gland 1
keratinocyte 1
papilla 1
endometrium 1
FGF7 (Homo sapiens)
Pain Link Frequency Relevance Heat
adenocard 71 99.00 Very High Very High Very High
Inflammation 69 97.64 Very High Very High Very High
cytokine 34 93.72 High High
antagonist 16 86.24 High High
agonist 60 69.44 Quite High
Adalimumab 1 68.00 Quite High
Infliximab 1 67.40 Quite High
methotrexate 22 64.24 Quite High
corticosteroid 1 62.32 Quite High
Osteoarthritis 13 50.00 Quite Low
Disease Link Frequency Relevance Heat
Alopecia 1 99.82 Very High Very High Very High
Wound Healing 8 99.32 Very High Very High Very High
Prostate Cancer 27 99.20 Very High Very High Very High
Breast Cancer 5 98.12 Very High Very High Very High
INFLAMMATION 72 97.64 Very High Very High Very High
Adenocarcinoma 4 96.20 Very High Very High Very High
Diabetes Mellitus 4 95.04 Very High Very High Very High
Hypertension 2 94.52 High High
Erectile Dysfunction 2 93.84 High High
Renal Disease 1 92.40 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Therefore, in studies using immunohistochemistry, the immunolocalized KGF in the cytoplasm of epithelial cells might indicate incorporated KGF through KGF receptor.
Positive_regulation (incorporated) of KGF in epithelial cells
1) Confidence 0.50 Published 2010 Journal Radiat Environ Biophys Section Body Doc Link PMC2855434 Disease Relevance 0.71 Pain Relevance 0.07
Therefore, in studies using immunohistochemistry, the immunolocalized KGF in the cytoplasm of epithelial cells might indicate incorporated KGF through KGF receptor.
Positive_regulation (incorporated) of KGF receptor in epithelial cells
2) Confidence 0.50 Published 2010 Journal Radiat Environ Biophys Section Body Doc Link PMC2855434 Disease Relevance 0.71 Pain Relevance 0.07
Glucocorticoids appear to decrease KGF production (impairing wound healing) while estrogen and progesterone increase KGF in mammary gland and endometrium (MacDonald and Hill 2002).
Positive_regulation (increase) of KGF in mammary gland associated with wound healing
3) Confidence 0.50 Published 2006 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC1661654 Disease Relevance 0.38 Pain Relevance 0.09
Bansal et al. (1997) described the expression of KGF mRNA in human breast cancer cell lines and purified populations of epithelial cells, Shaoul et al. (2006) found markedly increased KGF protein levels in the mucosal epithelium of patients with gastric inflammation, as well as in gastric adenocarcinoma.
Positive_regulation (increased) of KGF protein in epithelium associated with adenocarcinoma, inflammation and breast cancer
4) Confidence 0.47 Published 2010 Journal Radiat Environ Biophys Section Body Doc Link PMC2855434 Disease Relevance 0.83 Pain Relevance 0.09
A plausible explanation for the lack of KGF-induced (recombinant KGF) stimulated proliferation in the present study as well as for lacking radioprotection in the former study (Hille et al. 2003) had been the very low level of KGF receptor mRNA expression in the tumour cell cultures.
Positive_regulation (induced) of KGF associated with cancer
5) Confidence 0.44 Published 2010 Journal Radiat Environ Biophys Section Body Doc Link PMC2855434 Disease Relevance 0.45 Pain Relevance 0
Like other members of the FGF family, KGF is a heparin-binding molecule and heparin is required for maximal KGF stimulation through its receptor (Hsu et al 1999).
Positive_regulation (required) of KGF
6) Confidence 0.41 Published 2006 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC1661654 Disease Relevance 0.21 Pain Relevance 0.08
Like other members of the FGF family, KGF is a heparin-binding molecule and heparin is required for maximal KGF stimulation through its receptor (Hsu et al 1999).
Positive_regulation (stimulation) of KGF
7) Confidence 0.38 Published 2006 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC1661654 Disease Relevance 0.21 Pain Relevance 0.08
At any rate the results indicate that the detection of a real improvement in grip among POAH patients necessitates an increase of approximately 4.2 and 5.5 kgf in the right and left hands, respectively, upon application of the SDD.
Positive_regulation (increase) of kgf
8) Confidence 0.31 Published 2008 Journal The Open Orthopaedics Journal Section Body Doc Link PMC2687110 Disease Relevance 0.05 Pain Relevance 0
Glucocorticoids appear to decrease KGF production (impairing wound healing) while estrogen and progesterone increase KGF in mammary gland and endometrium (MacDonald and Hill 2002).
Positive_regulation (increase) of KGF in endometrium associated with wound healing
9) Confidence 0.17 Published 2006 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC1661654 Disease Relevance 0.38 Pain Relevance 0.09
Studies performed by the Shiseido Research Group indicate that adenosine, via A2B AR, might stimulate hair growth through fibroblast growth factor-7 gene expression upregulation in dermal papilla cells [57].
Positive_regulation (upregulation) of fibroblast growth factor-7 gene in papilla associated with adenocard and alopecia
10) Confidence 0.11 Published 2008 Journal Purinergic Signal Section Body Doc Link PMC2583210 Disease Relevance 1.06 Pain Relevance 0.23
Culig et al. showed in DU-145 human prostatic tumor cells that growth factors e.g., IGF-I, KGF, and EGF could drive AR activation without androgen [16].
Positive_regulation (activation) of KGF associated with prostate cancer
11) Confidence 0.05 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2812491 Disease Relevance 0.48 Pain Relevance 0.04
At least 30 different growth factors are relevant for the maintenance of gut mucosal integrity, including transforming growth factor beta (TGF-beta), insulin-like growth factor (IGF), keratinocyte-like growth factor (KGF), epidermal growth factor (EGF), growth hormone (GH), and the colony-stimulating factors (GM-CSF, G-CSF, and macrophage colony-stimulating factor [M-CSF]) (Dignass and Sturm 2001; Playford and Ghosh 2005).
Positive_regulation (including) of keratinocyte-like growth factor in keratinocyte
12) Confidence 0.05 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2621411 Disease Relevance 0.65 Pain Relevance 0.36

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