INT199602

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Context Info
Confidence 0.70
First Reported 2006
Last Reported 2010
Negated 0
Speculated 2
Reported most in Body
Documents 12
Total Number 14
Disease Relevance 7.47
Pain Relevance 0.55

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (FGF7) extracellular space (FGF7) extracellular region (FGF7)
Golgi apparatus (FGF7)
Anatomy Link Frequency
keratinocytes 14
fibroblasts 2
HGF 2
papilla 2
FGF7 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 48 99.68 Very High Very High Very High
cytokine 24 99.16 Very High Very High Very High
adenocard 71 99.00 Very High Very High Very High
metalloproteinase 6 78.56 Quite High
agonist 60 69.44 Quite High
Pain 29 5.00 Very Low Very Low Very Low
Potency 26 5.00 Very Low Very Low Very Low
antagonist 16 5.00 Very Low Very Low Very Low
methotrexate 15 5.00 Very Low Very Low Very Low
cryotherapy 12 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Alopecia 1 99.82 Very High Very High Very High
INFLAMMATION 49 99.68 Very High Very High Very High
Cancer 816 99.08 Very High Very High Very High
Malignant Neoplastic Disease 39 96.48 Very High Very High Very High
Diabetes Mellitus 4 95.04 Very High Very High Very High
Hypertension 2 94.52 High High
Erectile Dysfunction 2 93.84 High High
Renal Disease 1 92.40 High High
Wound Healing 6 88.80 High High
Adhesions 7 88.72 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
KGF mRNA expression in fibroblasts was increased after 24 h.
Positive_regulation (increased) of Gene_expression (expression) of KGF mRNA in fibroblasts
1) Confidence 0.70 Published 2010 Journal Radiat Environ Biophys Section Body Doc Link PMC2855434 Disease Relevance 0.58 Pain Relevance 0
Primary keratinocytes (KTC) as well as HaCat cells showed increased KGF mRNA expression after irradiation at 6 and 24 h, and at both radiation doses of 1 and 4 Gy.
Positive_regulation (increased) of Gene_expression (expression) of KGF mRNA in KTC
2) Confidence 0.70 Published 2010 Journal Radiat Environ Biophys Section Body Doc Link PMC2855434 Disease Relevance 0.59 Pain Relevance 0
We now tested whether irradiation would increase the KGF receptor expression.
Spec (whether) Positive_regulation (increase) of Gene_expression (expression) of KGF receptor
3) Confidence 0.70 Published 2010 Journal Radiat Environ Biophys Section Body Doc Link PMC2855434 Disease Relevance 0.52 Pain Relevance 0
Figure 2b shows that KGF recptor mRNA expression in primary keratinocytes is upregulated at both time points and radiation doses, while KGF receptor mRNA expression in HaCat cells is nearly unaffected by radiation.


Positive_regulation (upregulated) of Gene_expression (expression) of KGF recptor mRNA in keratinocytes
4) Confidence 0.70 Published 2010 Journal Radiat Environ Biophys Section Body Doc Link PMC2855434 Disease Relevance 0.19 Pain Relevance 0
Keratinocyte growth factor expression seems mediated by pro-inflammatory cytokines like TNF-?
Spec (seems) Positive_regulation (mediated) of Gene_expression (expression) of Keratinocyte growth factor in Keratinocyte associated with inflammation and cytokine
5) Confidence 0.57 Published 2006 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC1661654 Disease Relevance 0.24 Pain Relevance 0.10
Unexpectedly, we also found KGF mRNA and protein expression in primary keratinocytes, RNA expression being up-regulated by irradiation.
Positive_regulation (found) of Gene_expression (found) of KGF mRNA in keratinocytes
6) Confidence 0.50 Published 2010 Journal Radiat Environ Biophys Section Body Doc Link PMC2855434 Disease Relevance 0.45 Pain Relevance 0
Unexpectedly, we also found KGF mRNA and protein expression in primary keratinocytes, RNA expression being up-regulated by irradiation.
Positive_regulation (found) of Gene_expression (expression) of KGF mRNA in keratinocytes
7) Confidence 0.50 Published 2010 Journal Radiat Environ Biophys Section Body Doc Link PMC2855434 Disease Relevance 0.45 Pain Relevance 0
For confirmation, immortalized keratinocytes (HaCat cells) were tested and showed KGF mRNA expression and secretion as well.
Positive_regulation (showed) of Gene_expression (expression) of KGF mRNA in keratinocytes
8) Confidence 0.50 Published 2010 Journal Radiat Environ Biophys Section Body Doc Link PMC2855434 Disease Relevance 0.36 Pain Relevance 0
Consistent with this hypothesis, paracrine growth factors that are normally secreted by prostate stroma cells, such as epidermal growth factor (EGF), insulin-like growth factor 1 (IGF1), hepatocyte growth factor (HGF), keratinocyte growth factor (KGF) or interleukin 6 (IL6), are found to be overexpression in hormone-refractory cancer in association with a switch to autocrine production by cancer epithelial cells [16].
Positive_regulation (overexpression) of Gene_expression (overexpression) of KGF in HGF associated with cancer
9) Confidence 0.49 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2957443 Disease Relevance 0.73 Pain Relevance 0
Figure 2a summarizes the results; the mRNA expression is normalized to the unirradiated controls.Fig. 2a Radiation-induced changes in KGF expression in normal (KTC = primary keratinocytes, HaCat = immortalized keratinocytes, DF-19 = primary fibroblasts) and tumour cells (BW-225, ZMK-1, GR-145, OH-65).
Positive_regulation (induced) of Gene_expression (expression) of KGF in keratinocytes associated with cancer
10) Confidence 0.47 Published 2010 Journal Radiat Environ Biophys Section Body Doc Link PMC2855434 Disease Relevance 0.45 Pain Relevance 0
To test for stimulating effects of KGF, cells were either plated in cell culture supernatants obtained as described under “Determination of the amount of KGF in cell culture supernatants” or in rHuKGF-containing medium at concentrations from 0.2 to 1 ?
Positive_regulation (stimulating) of Gene_expression (effects) of KGF
11) Confidence 0.44 Published 2010 Journal Radiat Environ Biophys Section Body Doc Link PMC2855434 Disease Relevance 0.11 Pain Relevance 0
Interestingly, some authors observed increased expression of the KGF/KGF receptor in more-differentiated and less-advanced tumors, and absence of expression in malignant versus benign cells or a switch to FGF receptor isoforms with low binding affinity to KGF (Oelmann et al 2004).
Positive_regulation (increased) of Gene_expression (expression) of KGF associated with malignant neoplastic disease and cancer
12) Confidence 0.41 Published 2006 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC1661654 Disease Relevance 0.87 Pain Relevance 0.11
Interestingly, some authors observed increased expression of the KGF/KGF receptor in more-differentiated and less-advanced tumors, and absence of expression in malignant versus benign cells or a switch to FGF receptor isoforms with low binding affinity to KGF (Oelmann et al 2004).
Positive_regulation (increased) of Gene_expression (expression) of KGF associated with malignant neoplastic disease and cancer
13) Confidence 0.41 Published 2006 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC1661654 Disease Relevance 0.87 Pain Relevance 0.11
Studies performed by the Shiseido Research Group indicate that adenosine, via A2B AR, might stimulate hair growth through fibroblast growth factor-7 gene expression upregulation in dermal papilla cells [57].
Positive_regulation (upregulation) of Gene_expression (expression) of fibroblast growth factor-7 gene in papilla associated with adenocard and alopecia
14) Confidence 0.08 Published 2008 Journal Purinergic Signal Section Body Doc Link PMC2583210 Disease Relevance 1.06 Pain Relevance 0.23

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